Emerging strategies for enhancing the homing of hematopoietic stem cells to the bone marrow after transplantation

Experimental Cell Research
Vikas Chander, Gurudutta Gangenahalli

Abstract

Bone marrow failure is the primary cause of death after nuclear accidents or intentional exposure to high or low doses of ionizing radiation. Hematopoietic stem cell transplantation is the most potent treatment procedure for patients suffering from several hematopoietic malignancies arising after radiation injuries. Successful hematopoietic recovery after transplantation depends on efficient homing and subsequent engraftment of hematopoietic stem cells in specific niches within the bone marrow. It is a rapid and coordinated process in which circulating cells actively enter the bone marrow through the process known as transvascular migration, which involves the tightly regulated relay of events that finally leads to homing of cells in the bone marrow. Various adhesion molecules, chemokines, glycoproteins, integrins, present both on the surface of stem cells and sinusoidal endothelium plays a critical role in transvascular migration. But despite having an in-depth knowledge of homing and engraftment and the key events that regulate it, we are still not completely able to avoid graft failures and post-transplant mortalities. This deems it necessary to design a flawless plan for successful transplantation. Here, in this review, we ...Continue Reading

References

Oct 19, 2001·Bone Marrow Transplantation·P J AmroliaD K Webb
Oct 24, 2001·Journal of Hematotherapy & Stem Cell Research·J L LiesveldC N Abboud
Oct 11, 2003·Experimental Hematology·Huib M Vriesendorp
Dec 17, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Isabel Barao, William J Murphy
Feb 3, 2005·Stem Cells and Development·Anand P Jillella, Celalettin Ustun
Jul 17, 2007·Seminars in Hematology·Robert Möhle, Lothar Kanz
Aug 19, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christopher M WalkerDaniel J Weisdorf
Jan 1, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jonas MattssonRainer Storb
Oct 4, 2008·Current Opinion in Hematology·Douglas R Adkins, John F DiPersio
Oct 14, 2008·Stem Cells and Development·Hilal GulAnna Janowska-Wieczorek
Apr 14, 2009·Bone Marrow Transplantation·M TrivediE D Ball
Nov 10, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andrea BacigalupoMary Horowitz
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Zengli ZhangJian Tong
Aug 13, 2010·Nature·Simón Méndez-FerrerPaul S Frenette

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