Emerging Targeted Therapies for the Treatment of Non-small Cell Lung Cancer

Current Oncology Reports
Patrick R HallidayTrever G Bivona

Abstract

Lung cancer remains the leading cause of cancer-related mortality worldwide. Genetic and molecular profiling of non-small cell lung cancer (NSCLC) has led to the discovery of actionable oncogenic driver alterations, which has revolutionized treatment for this disease. This review will move beyond traditional mutational drivers such as EGFR and ALK and will instead focus on emerging targets and the efficacy of new precision therapies. Here, we discuss both established and emerging targeted therapy approaches, as well as ongoing challenges for the treatment of NSCLC patients harboring oncogenic alterations of the following types-gene fusions (ROS1, RET, NTRK), receptor tyrosine kinases (MET amplification and exon 14 mutations and EGFR/HER2 exon 20 insertion mutations), and MAPK signaling (SHP2 and altered BRAF and NF1). The treatment of lung cancer is increasingly biomarker-driven, as patients are selected for targeted agents based on the identification of genetic alterations amenable to inhibition. Our ability to further improve patient outcomes with this precision medicine approach will require continued efforts to identify, characterize, and target lesions driving lung cancer tumorigenesis and progression.

References

Jan 1, 1986·Annals of the New York Academy of Sciences·S A SørensenA Nielsen
Jan 7, 2000·American Journal of Epidemiology·S A Rasmussen, J M Friedman
Jun 27, 2003·Trends in Biochemical Sciences·Benjamin G NeelLily Pao
Dec 18, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U GatzemeierV Hirsh
Jan 7, 2006·Cancer Research·Monica Kong-BeltranRobert Yauch
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·James BeanWilliam Pao
Jul 23, 2009·Cancer Science·Takashi MatozakiHiroshi Ohnishi
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul K PaikGregory J Riely
Sep 1, 2011·Nature Reviews. Endocrinology·Yuri E Nikiforov, Marina N Nikiforova
Dec 1, 2011·Therapeutic Advances in Medical Oncology·Shawna Leslie Organ, Ming-Sound Tsao
Jan 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristin BergethonA John Iafrate
Jan 31, 2012·The Lancet Oncology·Rafael RosellUNKNOWN Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia T
Feb 14, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J De GrèveD Schallier
Feb 14, 2012·Nature Medicine·Kengo TakeuchiYuichi Ishikawa
Jul 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria E ArcilaMarc Ladanyi
Jul 17, 2012·Cancer Discovery·Kimberly Brown DahlmanWilliam Pao
Nov 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rui WangHaiquan Chen
Dec 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin B KimKarl D Lewis
Apr 24, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julien MazièresOliver Gautschi
Jul 9, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephanie CardarellaPasi A Jänne
Oct 29, 2013·Nature Medicine·Aria VaishnaviRobert C Doebele
Mar 29, 2014·Cancer Discovery·Luc FribouletJeffrey A Engelman
Sep 30, 2014·The New England Journal of Medicine·Alice T ShawA John Iafrate
Dec 4, 2014·The New England Journal of Medicine·Benjamin J SolomonUNKNOWN PROFILE 1014 Investigators
Jul 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Oliver GautschiJulien Mazières
Oct 16, 2015·Nature·Chao ZhangGideon Bollag
Nov 26, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J MazièresO Gautschi
Dec 30, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Claire TissotPierre-Jean Souquet
Jan 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark M AwadLynette M Sholl
Feb 11, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amanda J RedigPasi A Janne

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Citations

Jan 10, 2020·Expert Review of Respiratory Medicine·Carlo GenovaFrancesco Grossi
Jun 24, 2020·International Journal of Cancer. Journal International Du Cancer·Yingcheng WuRenfang Mao
Jul 2, 2020·International Journal of Molecular Sciences·Victoria SarneRita Seeboeck
May 23, 2020·International Journal of Clinical Oncology·Xiaoqing YuYun Fan
Sep 6, 2019·Journal of Hematology & Oncology·Kevin ZarrabiShenhong Wu
Sep 11, 2020·Journal of Cellular and Molecular Medicine·Zhenxing WangFengwu Lin
Aug 15, 2019·Expert Review of Respiratory Medicine·Niki KarachaliouRafael Rosell
Aug 21, 2019·Cancers·Aubhishek ZamanTrever G Bivona
Feb 23, 2020·The International Journal of Biological Markers·Paola Ulivi
Dec 11, 2019·Technology in Cancer Research & Treatment·Jian-Hua GeChun-Lai Zhang
Dec 25, 2019·Signal Transduction and Targeted Therapy·Min YuanQing Xu
Nov 17, 2020·Chemical Biology & Drug Design·Rati Kailash Prasad Tripathi, Senthil Raja Ayyannan
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae Heun ChungDo Hyung Kim
Oct 27, 2020·Frontiers in Oncology·Evgeny N ImyanitovIlya V Tsimafeyeu
Dec 17, 2020·Signal Transduction and Targeted Therapy·Min YuanQing Xu
Mar 22, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Cheng-Yi WangCheng-Wen Wu
Apr 17, 2021·Pathology, Research and Practice·Ilenia ChatziandreouAngelica A Saetta
Jul 18, 2020·Biochimica Et Biophysica Acta. General Subjects·Reem EldawudCerasela Zoica Dinu
May 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ze-Bo JiangElaine Lai-Han Leung
May 25, 2021·Frontiers in Cell and Developmental Biology·You ZhouJingting Jiang
Jul 10, 2021·Critical Reviews in Oncology/hematology·Jasmine KaurMing Q Wei
Jul 10, 2021·Angewandte Chemie·Shipeng HeChunquan Sheng
Nov 13, 2021·Cell Death & Disease·Kathryn DavidsonTyson V Sharp

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