Emerging targets for the pharmacological treatment of depression: focus on melatonergic system

Current Medicinal Chemistry
Mario Catena-Dell'OssoCesario Bellantuono

Abstract

Depression is a disabling condition which adversely affects a person's family, social and work life, and that is associated with a heavy burden to society. Although the available antidepressants have shown their effectiveness and have greatly improved the prognosis of the disorder, the current management of depression is far from being satisfactory. In the last years, besides the classical research involving serotonin, norepineprine and dopamine, non-monoaminergic mechanisms have been explored in the attempt to discover new antidepressants. One such innovative approach focused on melatonergic system, as melatonin is involved in synchronizing circadian rhythms, which are known to be altered in depression. This narrative review aims to provide a comprehensive overview of different aspects of the melatonergic system, including biochemical and anatomical characteristics, impact on the sleep/wake system, and implications for the treatment of depression. In particular, the observation that melatonin may promote sleep and synchronize the internal clock led to development of high-affinity agonists for melatonin receptors (MT). Agomelatine, a naphthalene bioisostere of melatonin, which combines a potent MT1 and MT2 agonism with 5-HT(2C)...Continue Reading

Citations

Feb 2, 2013·CNS Spectrums·Mario Catena-Dell'OssoDonatella Marazziti
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Sep 1, 2018·Pharmacological Reports : PR·Dasiel O Borroto-EscuelaKjell Fuxe
Mar 26, 2021·Chronobiology International·Natalia Kurhaluk

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