Emerging technologies in therapeutic ultrasound: thermal ablation to gene delivery

Human Cell
Katsuro Tachibana

Abstract

Ultrasound is used today in medicine as a modality for diagnostic imaging. Recently, there have been numerous reports on the application of thermal and nonthermal ultrasound energy for treating various diseases. In addition to thermal ablation of tumors, non-thermal ultrasound combined with drugs and genes have led to much excitement especially for cancer treatment, vascular diseases, and regenerative medicine. Ultrasound energy can enhance the effects of thrombolytic agents such as urokinase for treatment of stroke and acute myocardial infarction. New ultrasound technologies have resulted in advanced devices such as a) ultrasound catheters, b) Non-invasive methods as high intensity focused ultrasound (HIFU) in conjunction with MRI and CT is already being applied in the clinical field, c) Chemical activation of drugs by ultrasound energy for treatment of tumors is another new field recently termed "Sonodynamic Therapy", and d) Combination of genes and microbubble have induced great hopes for ideal gene therapy (sonoporation). Various examples of ultrasound combined modalities are under investigation which could lead to revolutionary therapy.

References

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Citations

Jul 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian E O'Neill, King C P Li
Jun 25, 2010·Bubble Science Engineering and Technology·Shashank Sirsi, Mark Borden
Jan 7, 2014·Biological & Pharmaceutical Bulletin·Nobuhito HamanoYukihiko Aramaki
Feb 20, 2014·Drug Delivery·Bita TaghizadehZaynab Derakhshani
Sep 20, 2007·Technology in Cancer Research & Treatment·Vladimir G ZarnitsynMark R Prausnitz
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Ryu HirayamaJunzo Nakamura
Jan 8, 2015·International Journal of Radiation Biology·Xinna WangChuanshan Xu
Jun 21, 2006·Ultrasound in Medicine & Biology·Robyn K SchlicherMark R Prausnitz
Aug 29, 2021·Journal of Medical Ultrasonics·Loreto B FerilKatsuro Tachibana

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