Emerging Therapeutics for Ocular Surface Disease

Current Allergy and Asthma Reports
L Bielory, Dovid Schoenberg

Abstract

The purpose of this article is to review treatment advances in ocular allergy that include the treatment of the various signs and symptoms of the allergic inflammatory response of the ocular surface. Recent studies have demonstrated improved pharmacological effect of topical agents with artificial tears and cold compresses; brimonidine, a new ophthalmic decongestant which has demonstrated decreased rebound conjunctivitis; and potential use of contact lens and other novel delivery instruments to increase medication retention time. Currently, there have been limited advances in novel ophthalmic treatments. Non-pharmacological interventions have demonstrated in a randomized control study that artificial tears and the use cold compresses alone or in combination with ophthalmic antihistamines can enhance the effectiveness of a traditional pharmacological therapy. The primary advances have been the start of head-to-head studies comparing various agents actively being used in the treatment of ocular allergy. In addition, there has been increasing interest in the development of novel delivery systems to increase residence time of pharmacological agents in the ocular surface such as nanoparticles, microfilms; examining novel pathways of...Continue Reading

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Citations

May 6, 2019·Drugs & Aging·Erminia RidoloC Incorvaia
Aug 30, 2019·Current Opinion in Allergy and Clinical Immunology·Leonard Bielory, Dovid Schoenberg
Jul 1, 2020·Expert Opinion on Pharmacotherapy·Ibtesham T HossainBita Manzouri
Jun 25, 2019·Current Opinion in Allergy and Clinical Immunology·Rubba Shoukat KhanLeonard Bielory
Jul 25, 2019·International Journal of Molecular Sciences·Airi Jo-WatanabeTakehiko Yokomizo
Sep 19, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Amruta Trivedi, Constance Katelaris
Oct 29, 2020·Allergy and Asthma Proceedings·Leonard Bielory
Dec 5, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jonathan RodriguesDana V Wallace
Jan 1, 2021·Oxidative Medicine and Cellular Longevity·Lei Xi

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