Emerging therapies in adult and paediatric bronchiectasis

Respirology : Official Journal of the Asian Pacific Society of Respirology
Kate H Regan, Adam T Hill

Abstract

Bronchiectasis is a chronic respiratory disorder characterized by persistent productive cough and recurrent chest infections secondary to permanent structural airway damage. The current treatment strategies for this debilitating disorder are limited to prompt antibiotic treatment of infective exacerbations and regular airway clearance techniques. Despite its high morbidity and associated mortality across all age groups, it has been a neglected area of research in respiratory medicine and there remain no licensed disease-modifying therapies. In this review, we have explored the numerous potential therapeutic targets to break the vicious cycle of infection and inflammation seen in these patients and the novel therapeutic agents that have been developed to target them. We have reviewed the role of novel anti-inflammatory agents designed to target the persistent neutrophilic inflammatory infiltrate seen in bronchiectatic airways, including neutrophil elastase inhibitors, CXCR2 (CXC chemokine receptor 2) antagonists, DPP-1 (dipeptidyl peptidase 1) inhibitors, PDE4 (phosphodiesterase 4) inhibitors and statins. Furthermore, we have explored novel targets to improve mucociliary clearance, namely ENaC (epithelial sodium channel) inhibit...Continue Reading

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Citations

Feb 12, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anne B Chang, Keith Grimwood
Aug 20, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Adam T Hill, Anne B Chang
Jul 9, 2020·Expert Review of Respiratory Medicine·Fabio CardinaleFrancesco Menzella
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Holly R Keir, James D Chalmers
Aug 6, 2021·ERJ Open Research·Irisz Delestre-LevaiMaria Carmela De Vuono

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