Emerging Therapies in Neovascular Age-Related Macular Degeneration in 2020.

Asia-Pacific Journal of Ophthalmology
Anindya SamantaJay Chhablani

Abstract

Age-related macular degeneration (AMD) is one of the most common causes of vision loss. Advanced forms of AMD are seen in primarily 2 types-neovascular AMD (nAMD) with the presence of choroid neovascularization and nonneovascular AMD (nnAMD) with geographic atrophy. Although there are 4 anti-vascular endothelial growth factor drugs either widely used or approved for the former, there are no current treatments for the latter. This review will highlight upcoming treatments for AMD currently in clinical trials. For nAMD: Abicipar pegol, an intravitreal anti-vascular endothelial growth factor based on designed ankyrin repeat proteins (DARP) in protein, is currently pending approval. Conbercept and Faricimab, 2 intravitreal anti-growth factors, are currently in phase 3. Nine other upcoming agents have at least produced results in the 2A phase including intravitreal injections (KSI-301, OPT-302, RGX-314, ICON-1, and DE-122), depot (GB-102), drug reservoir (PDS), topical drops (PAN-90806), and oral formulations (AKST4290). We summarize all the newer molecules.

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Citations

Jan 30, 2021·Asia-Pacific Journal of Ophthalmology·Suber S Huang
Oct 3, 2020·Expert Opinion on Biological Therapy·Danny S C NgTimothy Y Y Lai
Mar 7, 2021·Antioxidants·Pachiappan ArjunanChristopher W Cutler
May 1, 2021·International Journal of Molecular Sciences·Manuela SantonocitoFrancesco Giuliano
Jun 3, 2021·Journal of Clinical Medicine·Prem Patel, Veeral Sheth
Jul 23, 2021·Therapeutic Advances in Ophthalmology·Priya R Chandrasekaran, V G Madanagopalan
Oct 3, 2021·International Journal of Retina and Vitreous·Sruthi Arepalli, Peter K Kaiser
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Jan 22, 2022·Expert Opinion on Therapeutic Targets·Amber T WolfThomas A Ciulla

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Methods Mentioned

BETA
dissection

Clinical Trials Mentioned

NCT02462928
NCT02462486
NCT03539549
NCT03790852
NCT04049266
NCT03345082
NCT01436864
NCT03577899
NCT03630952
NCT02484690

Software Mentioned

EMERGE
ARCHWAY
SEQUOIA
ALTISSIMO
AVENUE
GrayBug
AVANTE

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