Emerging Transcriptional Mechanisms in the Regulation of Epithelial to Mesenchymal Transition and Cellular Plasticity in the Kidney

Journal of Clinical Medicine
Letizia De Chiara, John Crean

Abstract

Notwithstanding controversies over the role of epithelial to mesenchymal transition in the pathogenesis of renal disease, the last decade has witnessed a revolution in our understanding of the regulation of renal cell plasticity. Significant parallels undoubtedly exist between ontogenic processes and the initiation and propagation of damage in the diseased kidney as evidenced by the reactivation of developmental programmes of gene expression, in particular with respect to TGFβ superfamily signaling. Indeed, multiple signaling pathways converge on a complex transcriptional regulatory nexus that additionally involves epigenetic activator and repressor mechanisms and microRNA regulatory networks that control renal cell plasticity. It is becoming increasingly apparent that differentiated cells can acquire an undifferentiated state akin to "stemness" which is leading us towards new models of complex cell behaviors and interactions. Here we discuss the latest findings that delineate new and novel interactions between this transcriptional regulatory network and highlight a hitherto poorly recognized role for the Polycomb Repressive Complex (PRC2) in the regulation of renal cell plasticity. A comprehensive understanding of how external...Continue Reading

References

Jul 1, 1995·The Journal of Cell Biology·F StrutzE G Neilson
Aug 27, 1993·Cell·J A KreidbergR Jaenisch
Jan 1, 1995·Acta Anatomica·E D Hay
Dec 12, 2001·Nature Cell Biology·Chuan-Wei JangRuey-Hwa Chen
Dec 31, 2002·American Journal of Physiology. Renal Physiology·Andras MassziAndrás Kapus
May 23, 2003·Journal of the American Society of Nephrology : JASN·Joseph V Bonventre
May 11, 2005·Kidney International·Tsutomu InoueEric G Neilson
Aug 10, 2005·Journal of Cellular Biochemistry·Shuan S Huang, Jung S Huang
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·Costanza SagrinatiPaola Romagnani
Dec 14, 2006·American Journal of Physiology. Renal Physiology·Tiffany CohenRoman Jednak
Feb 27, 2007·Cell·Tony Kouzarides
Nov 6, 2007·Journal of the American Society of Nephrology : JASN·Elena LazzeriPaola Romagnani
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Franca AnglaniAngela D'Angelo
Jun 4, 2008·Molecular and Cellular Biology·Nicolás HerranzSandra Peiró
Aug 20, 2008·Molecular and Cellular Biology·Deborah A Greer CardTrevor K Archer
Sep 13, 2008·Cell Stem Cell·Nimet MaheraliKonrad Hochedlinger
Dec 31, 2008·Cell Research·Ying E Zhang
Dec 31, 2008·Cell Research·Tetsuro Watabe, Kohei Miyazono
Jan 21, 2009·Cell Research·Jian XuRik Derynck
Mar 18, 2009·Developmental Cell·Mary Y Wu, Caroline S Hill
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Dec 17, 2009·The American Journal of Pathology·Benjamin D HumphreysJeremy S Duffield
Feb 13, 2010·The American Journal of Pathology·Ling LiFangming Lin
May 28, 2010·Expert Reviews in Molecular Medicine·Wendy C Burns, Merlin C Thomas

❮ Previous
Next ❯

Citations

May 27, 2017·Molecular Oncology·Mohit Kumar JollyHerbert Levine
Jan 29, 2020·Acta Physiologica·Adrienne M AssmusLinda J Mullins
Jan 10, 2018·Frontiers in Cell and Developmental Biology·Pasquale CocchiaroLuigi Michele Pavone
Jul 22, 2018·Journal of Biomedical Science·Michele Sook Yuin HiewTunku Kamarul
May 7, 2019·Frontiers in Pharmacology·Attila FinthaAttila Sebe
Mar 9, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lin ChenYing-Yong Zhao

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
ChIP-seq
dissection

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Fate Conversion By mRNA

mRNA-based technology is being studied as a potential technology that could be used to reprogram cell fate. This technique provides the potential to generate safe reprogrammed cells that can be used for clinical applications. Here is the latest research on cell fate conversion by mRNA.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis