Emerging translational approaches to target STAT3 signalling and its impact on vascular disease

Cardiovascular Research
Jochen DutzmannDaniel G Sedding

Abstract

Acute and chronic inflammation responses characterize the vascular remodelling processes in atherosclerosis, restenosis, pulmonary arterial hypertension, and angiogenesis. The functional and phenotypic changes in diverse vascular cell types are mediated by complex signalling cascades that initiate and control genetic reprogramming. The signalling molecule's signal transducer and activator of transcription 3 (STAT3) plays a key role in the initiation and continuation of these pathophysiological changes. This review highlights the pivotal involvement of STAT3 in pathological vascular remodelling processes and discusses potential translational therapies, which target STAT3 signalling, to prevent and treat cardiovascular diseases. Moreover, current clinical trials using highly effective and selective inhibitors of STAT3 signalling for distinct diseases, such as myelofibrosis and rheumatoid arthritis, are discussed with regard to their vascular (side-) effects and their potential to pave the way for a direct use of these molecules for the prevention or treatment of vascular diseases.

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Citations

Nov 11, 2015·Endocrine-related Cancer·Jeong Won ParkSheue-yann Cheng
Dec 17, 2016·Cardiovascular Research·Diane GalWouter Vandevelde
Jul 8, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Carlos Pérez-SánchezChary López-Pedrera
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Mar 9, 2021·Journal of Drug Targeting·Zhixian JiangJinning Zhang
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Aug 18, 2020·The American Journal of Pathology·Chiara MacchiMassimiliano Ruscica

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Clinical Trials Mentioned

NCT01047943
NCT00696176
NCT00910728
NCT01112397
NCT01219543
NCT01235871
NCT01904123
NCT01752335
NCT01331837
NCT01491074

Software Mentioned

STATTIC

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