Emerging treatment options for uterine fibroids

Expert Opinion on Emerging Drugs
Jacques DonnezMarie-Madeleine Dolmans

Abstract

Uterine fibroids (also known as leiomyomas or myomas) are the most common form of benign uterine tumors. Current management strategies involve mainly surgical interventions, but the choice of treatment is guided by patient age and desire to preserve fertility or avoid 'radical' surgery such as hysterectomy. Areas covered: There is growing evidence of the crucial role of progesterone pathways in the pathophysiology of uterine fibroids, leading to increasing use of selective progesterone receptor modulators (SPRMs) such as ulipristal acetate. We searched all published studies on medical management of fibroids with SPRMs. Expert opinion: The need for alternatives to surgical intervention is very real, especially for women seeking to preserve their fertility. These options now exist, with SPRMs proven to treat fibroid symptoms effectively. Gynecologists now have new tools in their armamentarium, opening up novel strategies for the management of uterine fibroids.

References

Feb 15, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Malcolm G MunroIan S Fraser
Jun 16, 2011·Molecular and Cellular Endocrinology·J Julie Kim, Elizabeth C Sefton
Feb 3, 2012·The New England Journal of Medicine·Jacques DonnezUNKNOWN PEARL I Study Group
Feb 3, 2012·The New England Journal of Medicine·Jacques DonnezUNKNOWN PEARL II Study Group
Sep 29, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Alistair R W WilliamsAlex Ferenczy
Sep 17, 2013·Journal of Women's Health·Elizabeth A StewartBijan J Borah
Oct 12, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Felice PetragliaCharles Chapron
Feb 15, 2014·World Journal of Clinical Cases·Elena LionettiMario La Rosa
Mar 19, 2014·Fertility and Sterility·Jacques DonnezUNKNOWN PEARL III and PEARL III Extension Study Group
Aug 31, 2014·Fertility and Sterility·Nathalie Chabbert-BuffetPhilippe Bouchard
Apr 23, 2015·The New England Journal of Medicine·Elizabeth A Stewart
May 25, 2015·Fertility and Sterility·Guillaume E CourtoyMarie-Madeleine Dolmans
Jun 15, 2015·Analytical and Bioanalytical Chemistry·Saskia SonnbergMiguel de la Guardia
Oct 16, 2015·BMJ : British Medical Journal·Mary Ann LumsdenMartha Hickey
Oct 20, 2015·Fertility and Sterility·Jacques DonnezErnest Loumaye
Jan 9, 2016·Clinical Obstetrics and Gynecology·Lauren A Wise, Shannon K Laughlin-Tommaso
Jan 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Miika MehineLauri A Aaltonen
Jul 29, 2016·Human Reproduction Update·Jacques Donnez, Marie-Madeleine Dolmans
Mar 8, 2017·PloS One·Bart C J M FauserAlistair R W William
Jan 1, 2014·Expert Review of Endocrinology & Metabolism·Elke Bestel, Jacques Donnez

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Citations

Jul 31, 2018·Expert Opinion on Drug Metabolism & Toxicology·Mohamed Ali, Ayman Al-Hendy
Jan 25, 2019·The Journal of Obstetrics and Gynaecology Research·Yeon Hee HongByung Chul Jee
Jun 5, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Tomasz ŁozińskiMichał Ciebiera
Jan 27, 2019·Nature Reviews. Disease Primers·Cynthia M FarquharJacky Boivin
Jul 25, 2020·Reproductive Biomedicine Online·Jacques Donnez, Marie-Madeleine Dolmans
May 7, 2021·Reproductive Biology and Endocrinology : RB&E·Maria Simone Oliveira LimaPedro Vitor Lopes Costa
Jul 20, 2021·Expert Opinion on Investigational Drugs·Susan DababouFabio Barra

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