Emerging treatments for atopic dermatitis.

The Journal of Dermatology
Norito Katoh

Abstract

Increasing information on the pathophysiology of atopic dermatitis (AD), accumulating data on cellular and molecular pathways in immunological reactions and inflammation, and the expansion of biotechnology and pharmacology have collectively contributed to the development of new pharmacological agents for AD. Novel pharmaceutical agents, including biologics targeting cytokines, which play pathogenetic roles in AD, for example, interleukin (IL)-4, IL-13, IL-31 and IL-22, Janus kinase inhibitors, phosphodiesterase 4 inhibitors and histamine H4 receptor antagonists, have been approved or are being developed. These agents are expected to be effective in AD patients with skin signs and/or symptoms that are refractory to conventional treatments. The development of novel drugs will accompany the use of predictive biomarkers for each agent in order to optimize treatment in each patient. Convenient tools that support self-decision-making by patients to reflect their preferences, which will increase treatment satisfaction and adherence, are also anticipated.

References

Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katia BonifaceFranck Morel
Mar 18, 2009·Immunological Reviews·Kamran GhoreschiJohn J O'Shea
Mar 20, 2009·Nature Immunology·Kamran GhoreschiJohn J O'Shea
May 15, 2009·The Journal of Allergy and Clinical Immunology·Kristine E NogralesEmma Guttman-Yassky
Nov 2, 2011·Acta Dermato-venereologica·Stephan NobbeGünther F L Hofbauer
May 29, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·N UmarD D Terris
Jan 30, 2013·Journal of Molecular Biology·Mark UltschCharles Eigenbrot
Dec 3, 2013·Journal of the American Academy of Dermatology·Lawrence F EichenfieldRobert Sidbury
Jan 1, 2014·The Journal of Allergy and Clinical Immunology·Ferda CevikbasMartin Steinhoff
May 14, 2014·Expert Opinion on Investigational Drugs·Peter Norman
May 20, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·K SzegediM A Middelkamp-Hup
Jul 19, 2015·Cytokine·Sarah M McCormick, Nicola M Heller
Aug 10, 2015·Cytokine·Richard D May, Michael Fung
Apr 12, 2016·Frontiers in Immunology·Verena Katharina RakerKerstin Steinbrink
Sep 2, 2016·International Archives of Allergy and Immunology·Sjors A KoppesSanja Kezic
Oct 4, 2016·The New England Journal of Medicine·Eric L SimpsonUNKNOWN SOLO 1 and SOLO 2 Investigators
Mar 2, 2017·The New England Journal of Medicine·Thomas RuzickaUNKNOWN XCIMA Study Group
Apr 21, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·A WollenbergUNKNOWN European Dermatology Forum (EDF), the European Academy of Dermatology and Venereology (EADV), the European Academy of Allerg
Jun 16, 2018·The Journal of Allergy and Clinical Immunology·Andreas WollenbergRené van der Merwe
Jun 23, 2018·Nature Reviews. Disease Primers·Stephan WeidingerAlan D Irvine
Jul 14, 2018·Frontiers in Immunology·Satoshi KuboYoshiya Tanaka
Oct 18, 2018·Experimental Dermatology·Emma Guttman-YasskyMichael A Zielinski
Nov 12, 2018·The Journal of Allergy and Clinical Immunology·Thomas WerfelLynn Purkins
Jan 15, 2019·The Journal of Investigative Dermatology·Lam C TsoiStephan Weidinger
Feb 27, 2019·Rheumatology·Massimo GadinaJohn J O'Shea
Mar 20, 2019·BMC Rheumatology·Julie M ParmentierAndrew J Long
Aug 10, 2019·The Journal of Allergy and Clinical Immunology·Ting-Lin B Yang, Brian S Kim
Aug 23, 2019·The Journal of Dermatology·Tsen-Fang TsaiAnna M Tallman
Aug 28, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·L EicherA Wollenberg
Oct 11, 2019·The Journal of Dermatology·Norito KatohKiwako Yamamoto-Hanada
Oct 18, 2019·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yael Renert-Yuval, Emma Guttman-Yassky
Nov 26, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas Bieber
Dec 2, 2019·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJonathan I Silverberg
Dec 19, 2019·Frontiers in Immunology·Farzan SolimaniKamran Ghoreschi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Expert Review of Clinical Immunology
Celina DubinEmma Guttman-Yassky
Annals of Dermatology
Jiyoung AhnEric Lawrence Simpson
Current Allergy and Asthma Reports
Evie Huang, Peck Y Ong
© 2021 Meta ULC. All rights reserved