Emerging trends in enzyme inhibition by multivalent nanoconstructs

Organic & Biomolecular Chemistry
Nasreddine KanfarPascal Dumy

Abstract

Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular targets, have been recently exploited for enzyme inhibition showing interesting properties such as improvement of inhibitory potency and selectivity. We review herein the recent results highlighting the potential of multivalent nanoconstructs for the inhibition of different enzymes, and the emerging trends in the generation and identification of multivalent clusters as enzyme inhibitors.

References

May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·G LoidlL Moroder
Oct 3, 1999·European Journal of Biochemistry·T SteinmetzerJ Stürzebecher
Feb 16, 2000·Journal of Peptide Science : an Official Publication of the European Peptide Society·G LoidlL Moroder
Apr 28, 2001·Chemistry & Biology·N SchaschkeL Moroder
Feb 14, 2002·Chemical Reviews·Joseph J Lundquist, Eric J Toone
Mar 30, 2002·Science·George M Whitesides, Bartosz Grzybowski
Jul 13, 2002·Bioorganic & Medicinal Chemistry Letters·Takeshi HondaMakoto Yamashita
Dec 20, 2002·Angewandte Chemie·Stuart J RowanJ Fraser Stoddart
Apr 17, 2003·Angewandte Chemie·Derk JoesterFrançois Diederich
Jan 15, 2004·Biological Chemistry·Trevor SelwoodNorman M Schechter
Mar 10, 2004·Bioorganic & Medicinal Chemistry Letters·Keith G WatsonWen-Yang Wu
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Simon J F MacdonaldSimon P Tucker
Jan 31, 2006·Angewandte Chemie·Rainer Haag, Felix Kratz
Feb 24, 2006·Organic & Biomolecular Chemistry·Marine GuillotFrançois Diederich
Mar 25, 2006·Angewandte Chemie·Laura L KiesslingLaura E Strong
Aug 8, 2006·Chembiochem : a European Journal of Chemical Biology·Yashveer SinghPascal Dumy
Sep 14, 2006·Chemical Reviews·Peter T CorbettSijbren Otto
Jan 11, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Marine Guillot-NieckowskiJean-Louis Gallani
Feb 1, 2007·Chemical Society Reviews·Jessica M DavisAndrew D Hamilton
Nov 22, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Didier BoturynPascal Dumy
Jan 3, 2008·Nature Reviews. Drug Discovery·Claudiu T Supuran
Jan 5, 2008·Organic & Biomolecular Chemistry·Sylvain Ladame
May 14, 2008·Journal of the American Chemical Society·Mary-Catherine BowmanChristian Melander
Dec 26, 2008·Organic & Biomolecular Chemistry·Jennifer DiotJosé Kovensky
Jan 7, 2009·The Journal of Biological Chemistry·Helen ConnarisGarry L Taylor
Jan 21, 2009·Bioorganic & Medicinal Chemistry Letters·Jérémie DoironMohamed Touaibia
Feb 19, 2010·Angewandte Chemie·Charles E Hoyle, Christopher N Bowman
Apr 13, 2010·Bioorganic & Medicinal Chemistry Letters·Paolo Di GianvincenzoSoledad Penadés
May 13, 2010·Chemical Society Reviews·Dana A UhlenheuerLuc Brunsveld
May 26, 2010·Chemical Reviews·Alessandro Dondoni, Alberto Marra
Aug 27, 2010·Journal of Pharmaceutical Sciences·Alisha K WeightAlexander M Klibanov
Sep 4, 2010·Biomaterials·Nathan P Gabrielson, Jianjun Cheng
Sep 8, 2010·Angewandte Chemie·Philippe CompainJean-François Nierengarten
Sep 30, 2010·Chemical Society Reviews·Meredith A Mintzer, Mark W Grinstaff
Dec 29, 2010·ACS Chemical Biology·Fabian BullerDario Neri
Feb 18, 2011·Angewandte Chemie·Mathieu GalibertDidier Boturyn
Apr 13, 2011·Chemical Communications : Chem Comm·Gilles Guichard, Ivan Huc

❮ Previous
Next ❯

Citations

May 4, 2016·Organic & Biomolecular Chemistry·Audrey HottinJean-Bernard Behr
Jun 30, 2016·Chemical Communications : Chem Comm·Sarah H Hewitt, Andrew J Wilson
Jul 5, 2016·Chemistry : a European Journal·Marta Abellán FlosStéphane P Vincent
Aug 16, 2016·Chemistry : a European Journal·Abdellatif TikadStéphane P Vincent
Jan 25, 2017·Organic & Biomolecular Chemistry·Alessandro Dondoni, Alberto Marra
Feb 23, 2017·Chemistry : a European Journal·Nasreddine KanfarJean-Yves Winum
Feb 28, 2017·Chemistry : a European Journal·M Isabel García-MorenoJosé M García Fernández
May 27, 2017·Chemistry : a European Journal·Dimitri Alvarez-DortaYves Blériot
Dec 28, 2017·Chemistry : a European Journal·Jean-François NierengartenPhilippe Compain
May 4, 2018·Angewandte Chemie·Eduardo HowardPhilippe Compain
Sep 14, 2017·Chemistry : a European Journal·Stefania MirabellaFrancesca Cardona
Dec 6, 2018·Chemistry : a European Journal·Yoan BrissonnetSébastien G Gouin
Apr 18, 2019·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Philippe Compain
May 31, 2019·Organic & Biomolecular Chemistry·Maëva M PichonPhilippe Compain
Oct 10, 2019·Chemical Communications : Chem Comm·Manuel González-CuestaCarmen Ortiz Mellet
Jan 7, 2016·Beilstein Journal of Organic Chemistry·Camilla MatassiniFrancesca Cardona
Apr 24, 2020·Chemical Communications : Chem Comm·Manuel González-CuestaJosé M García Fernández
Oct 21, 2017·Chemical Communications : Chem Comm·Jean-François Nierengarten
Aug 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Thi Minh Nguyet TrinhJean-François Nierengarten
Feb 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Juan-Juan LiXiao-Liu Li
Aug 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Carmen Ortiz MelletJosé M García Fernández
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min LiXiao-Liu Li
Oct 31, 2019·International Journal of Molecular Sciences·Fabrizio CartaJean-Yves Winum
Jan 3, 2021·International Journal of Biological Macromolecules·Amit DubeyAmaresh Kumar Sahoo
Nov 6, 2020·Chemistry : a European Journal·Coralie AssaillySébastien G Gouin
Apr 22, 2021·Organic & Biomolecular Chemistry·Irene Conforti, Alberto Marra
Jan 30, 2019·Bioorganic & Medicinal Chemistry·Yoan BrissonnetSébastien G Gouin
Jul 24, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Tereza Cristina Santos EvangelistaEmil Lindbäck
Aug 31, 2019·Journal of the American Chemical Society·Javier Ramos-SorianoNazario Martín
Aug 22, 2018·ACS Medicinal Chemistry Letters·Sarah F GiardinaFrancis Barany

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.