Emerging tumefactive MS after switching therapy from interferon-beta to fingolimod: A case report

Multiple Sclerosis and Related Disorders
M H HarirchianB Siroos

Abstract

We describe a case of tumefactive multiple sclerosis, based on characteristic imaging features and excluding alternative diagnoses, presented with relapse 18 weeks after switching betaferon to fingolimod. Recent reported cases of this paradoxical demyelinating reaction in a setting of fingolimod-related immune system alterations seem to be something more than an accidental event. Immune cell shifting underlying a genetic susceptibility factor has been suggested to participate in this disastrous adverse effect. It could be a warning sign which physicians should take it into account for better recognition of patients at risk and select candidates for this management.

References

Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ponnada A Narayana
Sep 12, 2007·AJNR. American Journal of Neuroradiology·Marc KalisRobert M Quencer
Jun 17, 2010·Nature Reviews. Neurology·Orhan AktasHans-Peter Hartung
Mar 16, 2012·Multiple Sclerosis : Clinical and Laboratory Research·A AltintasA Siva

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Citations

May 4, 2016·CNS Neuroscience & Therapeutics·Yara Dadalti Fragoso, Henry Koiti Sato
Jan 17, 2017·Internal Medicine·Masataka NakamuraHirofumi Kusaka
Jul 15, 2020·Multiple Sclerosis : Clinical and Laboratory Research·David CroteauCindy M Kortepeter
May 22, 2017·Acta neurologica Belgica·Yara Dadalti Fragoso
Sep 22, 2017·Clinical & Experimental Neuroimmunology·Fumihito YoshiiWakoh Takahashi

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