Emerging tumor spheroids technologies for 3D in vitro cancer modeling

Pharmacology & Therapeutics
Tânia RodriguesVitor M Correlo

Abstract

Cancer is a leading cause of mortality and morbidity worldwide. Around 90% of deaths are caused by metastasis and just 10% by primary tumor. The advancement of treatment approaches is not at the same rhythm of the disease; making cancer a focal target of biomedical research. To enhance the understanding and prompts the therapeutic delivery; concepts of tissue engineering are applied in the development of in vitro models that can bridge between 2D cell culture and animal models, mimicking tissue microenvironment. Tumor spheroid represents highly suitable 3D organoid-like framework elucidating the intra and inter cellular signaling of cancer, like that formed in physiological niche. However, spheroids are of limited value in studying critical biological phenomenon such as tumor-stroma interactions involving extra cellular matrix or immune system. Therefore, a compelling need of tailoring spheroid technologies with physiologically relevant biomaterials or in silico models, is ever emerging. The diagnostic and prognostic role of spheroids rearrangements within biomaterials or microfluidic channel is indicative of patient management; particularly for the decision of targeted therapy. Fragmented information on available in vitro sphe...Continue Reading

Citations

Oct 28, 2018·Biotechnology and Bioengineering·Ana S NunesIlídio J Correia
Jun 11, 2020·Biotechnology Progress·Larissa B TofaniKamilla Swiech
May 28, 2019·Gels·Andreas BlaeserDaniela F Duarte Campos
Aug 9, 2020·Frontiers in Bioengineering and Biotechnology·Meletios-Nikolaos DoulgkeroglouDimitrios I Zeugolis
Sep 3, 2019·Frontiers in Bioengineering and Biotechnology·Catarina Roma-RodriguesPedro V Baptista
Jun 5, 2020·Bulletin of Mathematical Biology·Catherine BerrouetNecibe Tuncer
Oct 22, 2020·International Journal of Molecular Sciences·Eliana SteinbergOfra Benny
Jan 14, 2021·Biomaterials Science·Kanishka FernandoEliza Li Shan Fong
May 26, 2020·Seminars in Cancer Biology·Prisca BustamanteJulia V Burnier
Nov 17, 2020·Advanced Healthcare Materials·Daniela F Duarte Campos, Laura De Laporte
Nov 19, 2020·IScience·Samaneh Kamali SarvestaniEmina H Huang
Nov 3, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Anheng WangVesselin N Paunov
Nov 22, 2020·Trends in Cancer·João RodriguesJai Prakash
Jan 30, 2021·Trends in Cancer·L Paige FergusonTannishtha Reya
Sep 16, 2020·Cancer Treatment Reviews·Anita SemertzidouMaria Kyrgiou
Mar 6, 2021·Cancer Cell International·Se Jik HanKyung Sook Kim
Jul 16, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jingwen XuXiuzhi Sun
Apr 14, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kathleen MolyneauxSusann M Brady-Kalnay
Apr 26, 2021·Advanced Drug Delivery Reviews·Marcel A HeinrichJai Prakash
Jul 3, 2021·Micromachines·Xiaoli LiuChengyun Zheng
Aug 10, 2021·Bioprinting·Thafar AlmelaKeyvan Moharamzadeh
Sep 26, 2021·Advanced Materials·Sang Ah YiKi-Bum Lee

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