PMID: 20650082Jun 1, 1995Paper

Emetine-induced lactate dehydrogenase release, functional changes and electrocardiographic changes in the rat heart in vitro

Toxicology in Vitro : an International Journal Published in Association with BIBRA
S J Pan, A B Combs

Abstract

Emetine is an old drug which is used primarily as a emetic in ipecac syrup and as an alternative amoebicide. The major problem with emetine is that chronic use causes severe cardiotoxicity. In order to explore the mechanism of emetine cardiotoxicity, simultaneous recordings of mechanical activity and electrocardiograms, and biochemical assays were performed on male Sprague-Dawley rat hearts perfused by the Langendorff technique. Emetine was perfused constantly at concentrations of 19 or 37 mum for 10 min. All of the effects of emetine were concentration dependent. The most significant toxicological effect was the large amounts of LDH which appeared in the coronary effluent. A significant degree of injury to the cardiac plasma membrane is indicated by this observation, since LDH normally is an intracellular enzyme. Such damage to the membrane might accumulate and lead to the chronic, cumulative cardiotoxicity observed clinically with emetine. The pharmacological effects of emetine perfusion included decreased contractility which occurred concurrently with P-R interval prolongation, QRS duration prolongation, and degeneration of the QRS waveform. Coronary flow increased early during emetine perfusion, but then dropped to below co...Continue Reading

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Citations

Aug 27, 2013·International Journal of Psychiatry in Clinical Practice·Moshe NussinovitchEitan Gur

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