Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways

Chemico-biological Interactions
Ji Hyun KimSang Yeol Lee

Abstract

Emetine is a natural compound originated from ipecac roots. It was commonly used as anti-protozoal and vomiting agent. The apoptosis-inducing effect of emetine makes it considered as a potential anti-cancer agent for various human cancers. Here in this study, we report that emetine inhibits migration and invasion of human non-small-cell lung cancer (NSCLC) cells. Modulation of three major mitogen-activated protein kinases (MAPKs), ERK, p38 and JNK, is well known to be involved in regulation of matrix metalloproteinases (MMPs), which are essential in tissue remodeling and extracellular matrix (ECM) degradation, for cancer cells to spread out from the origin of tumorigenesis. Emetine regulates two major MAPKs, p38 and ERK. Differential inhibition/stimulation of ERK and p38 induced differential suppressions of β-catenin and c-myc transcription factors. This leads to the selective down-regulation of MMP-2 and MMP-9, two major gelatinases which can degrade ECM components, and RECK, a negative regulator of MMP-9.

References

Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·C TakahashiM Noda
Nov 18, 1998·Current Opinion in Cell Biology·M JohnsenK Danø
Jul 26, 2003·Journal of Natural Products·Ilias MuhammadLarry A Walker
Sep 17, 2004·Journal of Cell Science·Cai HuangMichael D Schaller
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Sep 25, 2007·Nature Reviews. Cancer·Erik Sahai
Oct 4, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vera Rosenkranz, Michael Wink
Mar 17, 2011·Cancer Research·Anita Wolfer, Sridhar Ramaswamy
Apr 3, 2012·Cell·Chi V Dang
Feb 26, 2013·Archives of Pharmacal Research·Young Min KimSang Yeol Lee

❮ Previous
Next ❯

Citations

Apr 15, 2016·Journal of Medicinal Chemistry·Hongbo ZhengHongxiang Lou
Jun 9, 2016·Journal of Toxicology and Environmental Health. Part a·Ji-Hua NieJian Tong
Jun 8, 2018·Clinical and Translational Science·Jeremiah HadwenAlex MacKenzie
Oct 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·I-Hsuan ChenMing-Tse Sung
Dec 15, 2015·Oncotarget·S Elizabeth FranksRoger A Moorehead
Nov 30, 2019·International Journal of Molecular Sciences·Ti-Hui WuYa-Wen Lin
Jul 22, 2021·Cancer Cell International·Yanming LuoHaiyang Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.