EMF radiation at 2450 MHz triggers changes in the morphology and expression of heat shock proteins and glucocorticoid receptors in rat thymus

Life Sciences
M J Misa-AgustiñoE López-Martín

Abstract

Electromagnetic fields (EMFs) can act as inducers or mediators of stress response through the production of heat shock proteins (HSPs) that modulate immune response and thymus functions. In this study, we analyzed cellular stress levels in rat thymus after exposure of the rats to a 2.45 GHz radio frequency (RF) using an experimental diathermic model in a Gigahertz Transverse Electromagnetic (GTEM) chamber. In this experiment, we used H&E staining, the ELISA test and immunohistochemistry to examine Hsp70 and Hsp90 expression in the thymus and glucocorticoid receptors (GR) of 64 female Sprague–Dawley rats exposed individually to 2.45 GHz (at 0, 1.5, 3.0 or 12.0 W power). The 1 g averaged peak and mean SAR values in the thymus and whole body of each rat to ensure that sub-thermal levels of radiation were being reached. The thymus tissue presented several morphological changes, including increased distribution of blood vessels along with the appearance of red blood cells and hemorrhagic reticuloepithelial cells. Levels of Hsp90 decreased in the thymus when animals were exposed to the highest power level (12 W), but only one group did not show recovery after 24 h. Hsp70 presented no significant modifications in any of the groups. Th...Continue Reading

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Citations

Jun 10, 2017·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A KulaberE Odacı
Jul 20, 2018·Journal of Microscopy and Ultrastructure·Elfide Gizem KıvrakGamze Altun
Sep 24, 2019·Electromagnetic Biology and Medicine·Brunella Del ReGianfranco Giorgi
Apr 18, 2017·Experimental and Therapeutic Medicine·Xianliang DaiZonggui Wu
Jun 3, 2021·International Journal of Molecular Sciences·Haifa OthmanElena López-Martín
Jun 15, 2021·Environmental Research·Piotr PiszczekJolanta Kaszuba-Zwoińska

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