Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population.

BMC Medical Genetics
Chong ShenDongfeng Gu

Abstract

Elastogenesis of elastic extracellular matrix (ECM) which was recognized as a major component of blood vessels has been believed for a long time to play only a passive role in the dynamic vascular changes of typical hypertension. Emilin1 gene participated in the transcription of ECM's formation and was recognized to modulate links TGF-beta maturation to blood pressure homeostasis in animal study. Recently relevant advances urge further researches to investigate the role of Emilin1 gene in regulating TGF-beta signals involved in elastogenesis and vascular cell defects of essential hypertension (EH). We designed a two-stage case-control study and selected three single nucleotide polymorphisms (SNPs), rs3754734, rs2011616 and rs2304682 from the HapMap database, which covered Emilin1 gene. Totally 2,586 subjects were recruited from the International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). In stage 1, all the three SNPs of the Emilin1 gene were genotyped and tested within a subsample including 503 cases and 490 controls, significant SNPs would enter into stage 2 including 814 cases with hypertension and 779 controls and analyze on the basis of testing total 2,586 subjects. In stage 1, single locus analyses...Continue Reading

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Citations

May 29, 2012·International Journal of Medical Sciences·Chibo Liu, Bo Xi
Apr 2, 2014·American Journal of Hypertension·Jinfeng ChenSong Yang
Jul 23, 2014·Clinical and Experimental Hypertension : CHE·Yingshui YaoChong Shen
Apr 10, 2015·Clinical and Experimental Hypertension : CHE·Daoxia GuoYingshui Yao
Feb 27, 2010·American Journal of Hypertension·Masanori ShimodairaKoichi Matsumoto
Jul 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Gaia LitteriGiuseppe Lembo
Sep 2, 2016·Journal of Cancer Research and Clinical Oncology·Miroslava RabajdovaMaria Marekova
Jul 20, 2017·Scientific Reports·Bamaprasad DuttaSiu Kwan Sze
Apr 5, 2020·Neural Regeneration Research·Jun-Mou HongChao-Liang Tang

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Methods Mentioned

BETA
genotyping
electrophoresis
genetic modification

Software Mentioned

InterASIA
stats
HWE
R
haplo

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