Eml5, a novel WD40 domain protein expressed in rat brain

Gene
V O'ConnorP J French

Abstract

We have isolated a novel transcript with homology to the major microtubule-associated protein in dividing sea urchin embryos, EMAP. The protein has a predicted MW of approximately 180 kDa and we have named it Eml5 (EMAP-like protein 5). Eml5 contains 11 putative WD40 domains and 3 hydrophobic stretches of 43 aa, HELP domains, which have been suggested to be involved in microtubule binding. Eml5 appears to consist of two tandem repeats of the complete EMAP protein separated by a putative dimerization domain. Eml5 mRNA and protein is expressed at high levels in the hippocampus, cerebellum and olfactory bulb, as determined by in situ hybridization and immunocytochemistry. Eml5 transcripts can be detected in fore- and hindbrain structures from embryonic day 13 onwards. Because other EMAP-like proteins are involved in regulating microtubule dynamics, it is likely that Eml5 plays a role in the regulation of cytoskeletal rearrangements during neuronal development and in adult brain

References

Jun 1, 1989·Neuron·G LeeK S Kosik
Dec 1, 1981·The Journal of Cell Biology·S R HeidemannM A Hamborg
Mar 4, 1998·Current Opinion in Cell Biology·H C Joshi
May 16, 1998·The Journal of Biological Chemistry·D R HamillK A Suprenant
Feb 27, 1999·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T NagaseO Ohara
Apr 20, 1999·The Journal of Cell Biology·F J AhmadP W Baas
May 14, 1999·Trends in Biochemical Sciences·T F SmithE J Neer
Jun 17, 1999·Trends in Neurosciences·D van Rossum, U K Hanisch
Feb 19, 2000·Current Opinion in Cell Biology·C E Walczak
Jun 22, 2000·Nature Neuroscience·H HusiS G Grant
Sep 1, 2000·Brain Research. Brain Research Reviews·L BuéeP R Hof
Dec 15, 2000·Current Opinion in Structural Biology·A Lewit-Bentley, S Réty
Nov 6, 2001·The Journal of Biological Chemistry·Bernd EichenmullerKathy A Suprenant
Dec 6, 2001·Neuroscience·P J FrenchV O'Connor
Jan 17, 2002·Current Opinion in Cell Biology·Lynne Cassimeris
Jan 17, 2002·Current Opinion in Cell Biology·Michel Bornens
Feb 7, 2002·Biochemical and Biophysical Research Communications·C Dune LyRobert J Wenthold

❮ Previous
Next ❯

Citations

May 4, 2013·Biomaterials·Suresh K BalasubramanianLiya E Yu
Apr 3, 2014·Chemical Senses·Adrian M FischlTimothy S McClintock
Jun 14, 2014·BMC Genomics·Oscar RamirezTomas Marques-Bonet
Aug 8, 2006·Experimental Cell Research·Marc PollmannHans-Juergen Heidebrecht
Dec 3, 2016·Biochemical Society Transactions·Andrew M FryRichard Bayliss

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.