EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions.

Medical Hypotheses
Saranya VaradarajanShankargouda Patil

Abstract

Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPRIN, has been regarded as a target for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attachment and entry into the host cell. Since one of the routes of entry for the virus is the oral cavity, it becomes imperative to percept oral comorbidities such oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) in terms of EMMPRIN as a target for SARS-CoV-2. In the present paper, it is proposed that OSCC, by the virtue of upregulation of EMMPRIN expression, increases the susceptibility to coronavirus disease (COVID-19). In turn, COVID-19 in OSCC patients causes exhaustion of EMMPRIN receptor due to binding with 'S' receptor leading to a downregulation of related carcinogenesis events. We proposed that in the ACE-2 depleted situation in OSCC, EMMPRIN receptor might get high jacked by the COVID-19 virus for the entry into the host cells. Apart from the anti-monoclonal antibody,...Continue Reading

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Citations

Jan 30, 2021·Journal of Clinical Pharmacology·Elnaz KhaniTaher Entezari-Maleki
Mar 7, 2021·Journal of Clinical Medicine·Stéphane Derruau On Behalf Of Task Force Covid-Collège National des EnseignantS En Biologie Orale Cnesbo-France
Feb 20, 2021·International Journal of Biological Macromolecules·Nivya SharmaShashi Bala Singh
May 13, 2021·Basic & Clinical Pharmacology & Toxicology·Naveed Nazir ShahShowkeen Muzamil Bashir

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Methods Mentioned

BETA
co-immunoprecipitation
ELISA

Software Mentioned

EMMPRIN

Related Concepts

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Carcinoma, Squamous Cell

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