PMID: 29290631Jan 2, 2018Paper

Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Sheng-Lan TianQing-Bang Xu

Abstract

BACKGROUND Idiopathic pulmonary fibrosis (IPF) can severely damage lung function, which may result in death. Emodin is a major ingredient of rhubarb and has been proven to protect against lung disruptions. Our study focused on the potential medicinal effect of emodin against IPF. MATERIAL AND METHODS The experiment subjects were fully-grown male Sprague-Dawley rats with average weight of 180-220 kg. Histological analyses, Western blotting analysis, quantitative real-time PCR, and statistical analysis were used in the study. RESULTS We found that emodin significantly reduced lung structural distortion, collagen overproduction, massive inflammatory cells infiltration, proinflammatory cytokines expansion, and injuries caused by administration of bleomycin (BLM). Additionally, emodin suppressed the accumulation of p-IκBα and NF-κB, while stimulating the Nrf2-antioxidant signaling process in damaged lungs. Emodin inhibited epithelial-mesenchymal transition (EMT) induced by BLM in the lungs. Moreover, emodin suppressed the TGF-β1 expression and the downstream signal molecules p-Smad-2 and p-Smad-3, which are reinforced by BLM. Emodin can also reverse EMT-like shifts induced by recombinant TGF-β1 in alveolar epithelial cultured cells....Continue Reading

Citations

Dec 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Xinnan WuQing Ji
Jul 31, 2019·Free Radical Research·S Mohamad Reza NazifiKrzysztof K Zborowski
Aug 26, 2020·Chinese Journal of Integrative Medicine·Yan-Jie TuAi-Dong Yang
Feb 8, 2019·Oxidative Medicine and Cellular Longevity·Qinmei LiuXinxin Ci
Nov 27, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Mai A ZaafanAmr M Abdelhamid
Feb 28, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Xuezhi ZhangJun Guan
Jul 2, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Mingjuan CaoDingbo Tao
Sep 4, 2020·Phytotherapy Research : PTR·Sai Manohar ThotaVenketesh Sivaramakrishnan
Aug 31, 2020·Chinese Medicine·Hong XiangDeshi Dong
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yukun ZhangZhidong Liu
Jul 29, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Zihuan XiaChenliang Deng

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