Emotion recognition in Parkinson's disease after subthalamic deep brain stimulation: differential effects of microlesion and STN stimulation

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Marilena AielloRaffaella I Rumiati

Abstract

Deep brain stimulation of the subthalamic nucleus (STN-DBS) has acquired a relevant role in the treatment of Parkinson's disease (PD). Despite being a safe procedure, it may expose patients to an increased risk to experience cognitive and emotional difficulties. Impairments in emotion recognition, mediated both by facial and prosodic expressions, have been reported in PD patients treated with such procedure. However, it is still unclear whether the STN per se is responsible for such changes or whether others factors like the microlesion produced by the electrode implantation may also play a role. In this study we evaluated facial emotions discrimination and emotions recognition using both facial and prosodic expressions in 12 patients with PD and 13 matched controls. Patients' were tested in four conditions: before surgery, both in on and off medication, and after surgery, respectively few days after STN implantation before turning stimulator on and few months after with stimulation on. We observed that PD patients were impaired in discriminating and recognizing facial emotions, especially disgust, even before DBS implant. Microlesion caused by surgical procedure was found to influence patients' performance on the discriminatio...Continue Reading

References

Dec 1, 1976·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·H E Nelson
Feb 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·J F CaekebekeR A Roos
Aug 1, 1996·Italian Journal of Neurological Sciences·A R GiovagnoliE Capitani
Aug 6, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·G L DeferM Levivier
Aug 10, 1999·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·A J Lloyd
Apr 27, 2002·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P CaffarraA Venneri
Dec 6, 2002·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Yayoi KanKatsuki Nakamura
Mar 8, 2003·Archives of General Psychiatry·Frank SchneiderHans-Joachim Freund
Apr 12, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Vittorio Gallese
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Oct 10, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·James T H YipLeonard S W Li
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·U SchroederA O Ceballos-Baumann
May 4, 2004·Parkinsonism & Related Disorders·M SensiP G Data
Dec 25, 2004·Cognition·Alvin I Goldman, Chandra Sekhar Sripada
Jul 5, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·I AppollonioP Nichelli
Oct 22, 2005·Clinical Neuropharmacology·Pilar Salgado-PinedaAndré Nieoullon
Jan 18, 2006·Brain : a Journal of Neurology·Atsunobu SuzukiMitsuru Kawamura
May 19, 2007·Science·Paula M Niedenthal
Jun 7, 2007·Brain : a Journal of Neurology·Reiner Sprengelmeyer
Dec 11, 2007·Parkinsonism & Related Disorders·C GranzieraF J G Vingerhoets
Aug 19, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesca AssognaGianfranco Spalletta
Sep 17, 2008·Parkinsonism & Related Disorders·C A CooperH H Fernandez
Oct 31, 2008·Journal of Clinical and Experimental Neuropsychology·Rachel L C Mitchell, Sofia Barbosa Bouças
Dec 17, 2008·Lancet Neurology·Alim Louis BenabidPierre Pollak
Jan 27, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·David MaltêteDidier Hannequin
Mar 24, 2009·Journal of Neurosurgery·Michael PourfarDavid Eidelberg
Jul 1, 2009·Psychiatry Research·Nim TottenhamCharles Nelson
Sep 22, 2009·Journal of the Neurological Sciences·Michele K YorkJoseph Jankovic
Mar 17, 2010·Neuropsychology·Heather M Gray, Linda Tickle-Degnen
Mar 26, 2010·Journal of Clinical and Experimental Neuropsychology·Silke Paulmann, Marc D Pell
Aug 31, 2010·Brain : a Journal of Neurology·Alfonso FasanoAlberto Albanese
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel Weintraub, David J Burn
Jan 28, 2012·Acta neurochirurgica·Verena Eveline RozanskiKai Bötzel

❮ Previous
Next ❯

Citations

Nov 7, 2014·Journal of the International Neuropsychological Society : JINS·Cinzia CecchettoRaffaella Ida Rumiati
Mar 10, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Tiago A MestreMichael S Okun
Sep 28, 2018·Human Brain Mapping·Raul Martínez-FernándezPaul Krack
Mar 9, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Ryan RoemmichChris J Hass
Dec 12, 2018·Parkinson's Disease·Margaret T M Prenger, Penny A MacDonald

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.