Emotion regulation deficits in euthymic bipolar I versus bipolar II disorder: a functional and diffusion-tensor imaging study

Bipolar Disorders
Xavier CaserasMary L Phillips

Abstract

Emotion regulation deficits are a core feature of bipolar disorder. However, their potential neurobiological underpinnings and existence beyond bipolar I disorder remain unexplored. Our main goal was to investigate whether both individuals with bipolar I and bipolar II disorder show deficits in emotion regulation during an attention control task, and to explore the neurophysiological underpinnings of this potential deficit. Twenty healthy controls, 16 euthymic participants with bipolar I disorder, and 19 euthymic participants with bipolar II disorder completed psychometric and clinical assessments, a neuroimaging emotion regulation paradigm, and an anatomical diffusion-weighted scan. Groups were matched for age, gender, and verbal IQ. During the presence of emotional distracters, subjects with bipolar I disorder showed slowed reaction times to targets, and increased blood oxygenation level-dependent (BOLD) responses in the amygdala, accumbens, and dorsolateral prefrontal cortex, but not increased inverse functional connectivity between these prefrontal and subcortical areas, and altered white matter microstructure organization in the right uncinate fasciculus. Subjects with bipolar II disorder showed no altered reaction times, ...Continue Reading

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Citations

Feb 21, 2016·Journal of Affective Disorders·Franz Hozer, Josselin Houenou
Jul 28, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Henry W Chase, Mary L Phillips
Nov 30, 2015·Journal of Affective Disorders·S MarwahaL Jones
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Sep 13, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Charles Laidi, Josselin Houenou
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Jun 11, 2020·Bipolar Disorders·Anjali SankarHilary P Blumberg
May 2, 2018·International Journal of Environmental Research and Public Health·Guorong MaWei Wang
Aug 17, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Sonya F FoleyXavier Caseras
Jan 14, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Leila NabulsiDara M Cannon
May 4, 2021·International Journal of Bipolar Disorders·Marcel KurtzPhilipp Kanske

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Software Mentioned

Functional MRI of the Brain ( FMRIB )
3DClustSim
AFNI
ExploreDTI
FMRIB Linear Image Registration ( FLIRT )

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