Emotional exhaustion and overcommitment to work are differentially associated with hypothalamus-pituitary-adrenal (HPA) axis responses to a low-dose ACTH1-24 (Synacthen) and dexamethasone-CRH test in healthy school teachers

Stress : the International Journal on the Biology of Stress
Maren WolframBrigitte M Kudielka

Abstract

Evidence for a detrimental impact of chronic work stress on health has accumulated in epidemiological research. Recent studies indicate altered hypothalamus-pituitary-adrenal (HPA) axis regulation as a possible biological pathway underlying the link between stress and disease. However, the direction of dysregulation remains unclear, with reported HPA hyper- or hyporeactivity. To disentangle potential effects on different functional levels in the HPA axis, we examined responses using two pharmacological stimulation tests in 53 healthy teachers (31 females, 22 males; mean age: 49.3 years; age range: 30-64 years): a low-dose adrenocorticotrophic hormone (ACTH(1-24), Synacthen) test was used to assess adrenal cortex sensitivity and the combined dexamethasone-corticotropin releasing hormone (DEX-CRH) test to examine pituitary and adrenal cortex reactivity. Blood and saliva samples were collected at - 1,+15,+30,+45,+60,+90,+120 min. Emotional exhaustion (EE), the core dimension of burnout, was measured with the Maslach Burnout Inventory. Overcommitment (OC) was assessed according to Siegrist's effort-reward-imbalance model. We found a significant association between EE and higher plasma cortisol profiles after Synacthen (p = 0.045). ...Continue Reading

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Citations

Dec 4, 2015·International Journal of Environmental Research and Public Health·Ning TaoJiwen Liu
Nov 11, 2017·International Journal of Environmental Research and Public Health·Johannes Siegrist, Jian Li
Oct 11, 2017·Stress and Health : Journal of the International Society for the Investigation of Stress·Deirdre A KatzPatricia A Jennings
Dec 24, 2018·European Journal of Endocrinology·Ingibjörg H Jonsdottir, Anna Sjörs Dahlman
Aug 26, 2016·BMC Endocrine Disorders·Flavio A Cadegiani, Claudio E Kater
Mar 31, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Adam BayesGordon Parker
Apr 4, 2021·International Journal of Environmental Research and Public Health·Niclas Almén

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