Emotional hyper-reactivity and cardiometabolic risk in remitted bipolar patients: a machine learning approach

Acta Psychiatrica Scandinavica
Aroldo A DargélChantal Henry

Abstract

Remitted bipolar disorder (BD) patients frequently present with chronic mood instability and emotional hyper-reactivity, associated with poor psychosocial functioning and low-grade inflammation. We investigated emotional hyper-reactivity as a dimension for characterization of remitted BD patients, and clinical and biological factors for identifying those with and without emotional hyper-reactivity. A total of 635 adult remitted BD patients, evaluated in the French Network of Bipolar Expert Centers from 2010-2015, were assessed for emotional reactivity using the Multidimensional Assessment of Thymic States. Machine learning algorithms were used on clinical and biological variables to enhance characterization of patients. After adjustment, patients with emotional hyper-reactivity (n = 306) had significantly higher levels of systolic and diastolic blood pressure (P < 1.0 × 10-8 ), high-sensitivity C-reactive protein (P < 1.0 × 10-8 ), fasting glucose (P < 2.23 × 10-6 ), glycated hemoglobin (P = 0.0008) and suicide attempts (P = 1.4 × 10-8 ). Using models of combined clinical and biological factors for distinguishing BD patients with and without emotional hyper-reactivity, the strongest predictors were: systolic and diastolic blood...Continue Reading

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Citations

Jan 25, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·A G SzmulewiczS A Strejilevich
Aug 18, 2020·Nordic Journal of Psychiatry·Selçuk Özdin, Miraç Barış Usta
May 18, 2020·Bipolar Disorders·Aroldo A DargélUNKNOWN FACE-BD collaborators
Aug 23, 2020·International Journal of Environmental Research and Public Health·Rebecca A BernertFreddy Abnousi
Aug 3, 2020·Neuroscience and Biobehavioral Reviews·Mathilde BigotChantal Henry
Feb 2, 2021·International Journal of Bipolar Disorders·Niall M McGowanKate E A Saunders
Nov 5, 2021·International Journal of Bipolar Disorders·Margrethe Collier HøeghTrine Vik Lagerberg
Dec 4, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·M Sanchez-AutetM P García-Portilla

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