Emotional processes and stress in children affected by hereditary angioedema with C1-inhibitor deficiency: a multicenter, prospective study

Orphanet Journal of Rare Diseases
Livia SavareseMaria Francesca Freda

Abstract

Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is characterized by recurrent edema of unpredictable frequency and severity. Stress, anxiety, and low mood are among the triggering factors most frequently reported. Impaired regulation and processing of emotions, also known as alexithymia, may influence outcomes. The aim of this study was to confirm the presence of alexithymia and stress in children with C1-INH-HAE, to determine whether they are also present in children affected by other chronic diseases, and to investigate their relationship with C1-INH-HAE severity. Data from children with C1-INH-HAE (n = 28) from four reference centers in Italy were compared with data from children with type 1 diabetes (T1D; n = 23) and rheumatoid arthritis (RA; n = 25). Alexithymia was assessed using the Alexithymia Questionnaire for Children scale; perceived stress was assessed using the Coddington Life Event Scale for Children (CLES-C). Mean age (standard deviation [SD]) in the C1-INH-HAE, T1D, and RA groups was 11.8 (3.3), 11.7 (2.9), and 11.1 (2.6) years, respectively. Mean C1-INH-HAE severity score was 5.9 (2.1), indicating moderate disease. Alexithymia scores were similar among disease groups and suggestive of difficulti...Continue Reading

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Citations

Jul 26, 2019·Pediatric Transplantation·Vicky Lee NgJohn C Bucuvalas
Oct 9, 2019·Current Opinion in Otolaryngology & Head and Neck Surgery·C Eric Bailey, Michele M Carr
Jun 12, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Volker WahnChristina Weber-Chrysochoou
Nov 7, 2019·Current Opinion in Pediatrics·Neha Pancholy, Timothy Craig
Dec 19, 2019·Frontiers in Psychology·Maria Francesca FredaRaffaele De Luca Picione
Feb 4, 2019·Integrative Psychological & Behavioral Science·Raffaele De Luca PicioneGina Troisi
Oct 29, 2020·Allergy and Asthma Proceedings·Douglas T Johnston, R Christina Smith
Jan 7, 2021·Allergy and Asthma Proceedings·Livia SavareseMaria Francesca Freda
Jan 11, 2021·Orphanet Journal of Rare Diseases·Livia SavareseMaria Francesca Freda
Jan 26, 2021·Frontiers in Psychology·Andrew J LampiTanya M Evans

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