Empagliflozin reduces cardiovascular events, mortality and renal events in participants with type 2 diabetes after coronary artery bypass graft surgery: subanalysis of the EMPA-REG OUTCOME® randomised trial

Diabetologia
Subodh VermaBernard Zinman

Abstract

After coronary artery bypass graft (CABG) surgery in individuals with type 2 diabetes, there remains a considerable residual cardiovascular risk. In the EMPA-REG OUTCOME® trial in participants with type 2 diabetes and established cardiovascular disease, empagliflozin reduced the risk of cardiovascular death by 38%, all-cause mortality by 32%, hospitalisation for heart failure by 35% and incident or worsening nephropathy by 39% vs placebo when given in addition to standard of care. The aim of this post hoc analysis of the EMPA-REG OUTCOME® trial was to determine the effects of the sodium glucose cotransporter 2 inhibitor empagliflozin on cardiovascular events and mortality in participants with type 2 diabetes and a self-reported history of CABG surgery. The EMPA-REG OUTCOME® trial was a randomised, double-blind, placebo-controlled trial. Participants with type 2 diabetes and established cardiovascular disease were randomised 1:1:1 to receive placebo, empagliflozin 10 mg or empagliflozin 25 mg, once daily, in addition to standard of care. In subgroups by self-reported history of CABG (yes/no) at baseline, we assessed: cardiovascular death; all-cause mortality; hospitalisation for heart failure; and incident or worsening nephropat...Continue Reading

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Citations

Sep 29, 2018·Canadian Journal of Physiology and Pharmacology·Naresh KumarSubodh Verma
Aug 29, 2019·Current Topics in Medicinal Chemistry·Ban LiuBiao Yan
Feb 11, 2020·International Journal of Experimental Pathology·Ahmed A M Abdel-Hamid, Alaa El-Din L Firgany
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Methods Mentioned

BETA
coronary artery bypass
amputations
amputation
pharmacotherapy

Clinical Trials Mentioned

NCT01131676
NCT03057977
NCT03057951

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