Empathic behavior according to the state of others in mice

Brain and Behavior
Hiroshi UenoTakeshi Ishihara

Abstract

Empathic behavior is essential for social activities in social animals. Therefore, lack of empathy is a feature of several neuropsychiatric disorders. However, the underlying mechanisms of empathy and which animals possess it remain unclear. In this study, we investigated whether mice show empathic behavior. We tested mice for empathy-like behaviors toward conspecifics who were distressed. We investigated behavioral changes in cage-mate or stranger mice. When the conspecific mice were in a painful state, subject mice showed preferential approach behavior toward them, presumably recognizing the state. Both visual information and olfactory information are indispensable for this empathic behavior. These results suggest that the mouse recognizes the emotional state of the conspecific and engages in social interaction. The results of this study are useful for the elucidation of the causal mechanisms involved in neuropsychiatric disorders and may contribute in the development of novel treatment targets.

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Citations

Apr 11, 2019·Scientific Reports·Hiroshi UenoTakeshi Ishihara
Dec 11, 2019·Stress : the International Journal on the Biology of Stress·Yuxin Zheng, Zhiyi Zuo
Aug 4, 2019·Scientific Reports·Hiroshi UenoTakeshi Ishihara
Dec 25, 2019·Behavioural Neurology·Hiroshi UenoTakeshi Ishihara
Aug 27, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Amanda Ribeiro BarrosoJuliana Geremias Chichorro
Jan 13, 2021·Current Opinion in Neurobiology·Toni-Lee Sterley, Jaideep S Bains
Nov 3, 2020·Behavioural Pharmacology·Stewart S Cox, Carmela M Reichel
Oct 7, 2020·Neuroscience and Biobehavioral Reviews·Julen Hernandez-LallementMaria Carrillo

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