Empathy in stroke rats is modulated by social settings.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Kazutaka ShinozukaCesario V Borlongan

Abstract

Rodents display "empathy" defined as perceived physical pain or psychological stress by cagemates when co-experiencing socially distinct traumatic events. The present study tested the hypothesis that empathy occurs in adult rats subjected to an experimental neurological disorder, by allowing co-experience of stroke with cagemates. Psychological stress was measured by general locomotor activity, Rat Grimace Scale (RGS), and plasma corticosterone. Physiological correlates were measured by Western blot analysis of advanced glycation endproducts (AGE)-related proteins in the thymus. General locomotor activity was impaired in stroke animals and in non-stroke rats housed with stroke rats suggesting transfer of behavioral manifestation of psychological stress from an injured animal to a non-injured animal leading to social inhibition. RGS was higher in stroke rats regardless of social settings. Plasma corticosterone levels at day 3 after stroke were significantly higher in stroke animals housed with stroke rats, but not with non-stroke rats, indicating that empathy upregulated physiological stress level. The expression of five proteins related to AGE in the thymus reflected the observed pattern of general locomotor activity, RGS, and ...Continue Reading

References

Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·J M BrotchieA R Crossman
Oct 6, 2001·Stroke; a Journal of Cerebral Circulation·T A KentR H Fabian
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Nobuo SugoA Courtney DeVries
Aug 16, 2005·Stroke; a Journal of Cerebral Circulation·Tara K S CraftA Courtney DeVries
Jul 1, 2006·Science·Dale J LangfordJeffrey S Mogil
Oct 31, 2006·Oncogene·M S HaydenS Ghosh
Dec 29, 2006·Annals of the New York Academy of Sciences·George Mastorakos, Ioannis Ilias
Dec 15, 2007·The Journal of Clinical Investigation·Evis HarjaAnn Marie Schmidt
Apr 26, 2008·Stroke; a Journal of Cerebral Circulation·Michael T McCormickMatthew R Walters
Mar 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kate KarelinaA Courtney DeVries
Sep 8, 2009·Experimental Neurology·Kate KarelinaA Courtney DeVries
May 11, 2010·Nature Methods·Dale J LangfordJeffrey S Mogil
Nov 30, 2010·Biochemical and Biophysical Research Communications·Yunxia ZhuXiao Han
Jan 29, 2011·Pain·Henriette KlitTroels Staehelin Jensen
Jul 19, 2011·PloS One·Piray AtsakChristian Keysers
Aug 20, 2011·PloS One·Shigeru Watanabe
Nov 15, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shan ZengAnn Marie Schmidt
Dec 14, 2011·Science·Inbal Ben-Ami BartalPeggy Mason
Jan 4, 2012·Annals of the New York Academy of Sciences·Ravichandran RamasamyAnn Marie Schmidt
Apr 28, 2012·European Journal of Immunology·James Dooley, Adrian Liston
May 9, 2012·Acta Neuropathologica·Venugopal Reddy VennaLouise D McCullough
Oct 30, 2012·Biochimica Et Biophysica Acta·Guglielmo SorciRosario Donato
Jul 15, 2015·Current Vascular Pharmacology·Ke-Jie YinY Eugene Chen
Jan 20, 2017·Frontiers in Pharmacology·James YipYuchuan Ding
Feb 28, 2017·Molecular and Cellular Endocrinology·Nelly T FabreMaria Lúcia Correa-Giannella
May 28, 2017·Psychoneuroendocrinology·Luca CarnevaliAndrea Sgoifo
Nov 23, 2017·European Journal of Pharmacology·Jyh-Gang LeuYao-Jen Liang
Dec 5, 2018·Trends in Pharmacological Sciences·Damien GulliverMichael Kassiou
Mar 2, 2019·Communications Biology·Yasuhiko YamamotoHaruhiro Higashida

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Citations

Aug 22, 2021·Animal Cognition·Shigeru WatanabeCesario Borlongan
Nov 18, 2021·Biology Letters·M H Blystad

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
GTPase
environmental stress

Software Mentioned

Adobe
PhotoShop CS2

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