Emphasis on peanut lectin as a marker for granular cells

Virchows Archiv. A, Pathological Anatomy and Histopathology
K SchwechheimerR Waldherr

Abstract

Peanut lectin (PNL) binding to a total of 13 granular cell tumours was examined by means of the peroxidase antiperoxidase technique. The tumours included six tumourettes of the neurohypophysis, one malignant granular cell tumour of the brain, and six peripheral tumours of distinct locations. Every tumour studied showed intracytoplasmic fine granular PNL binding; after pretreatment with neuraminidase, the weakly positive reaction was enhanced to a great extent. In all tumours simultaneous examination for the detection of lysozyme and glial fibrillary acidic protein (GFAP) was also carried out. Lysozyme was negative in all cases, whereas GFAP expression could be demonstrated at the periphery of the malignant granular cell tumour of the brain. The data presented clearly demonstrate that PNL can be used as a histochemical marker for granular cells regardless of their location. The fact that the presence of lysozyme could not be proved does not support the view of a histiocytic origin for granular cells, whereas the expression of GFAP in some immature granular cells of the brain tumour examined is considered to be an argument in favor of its glial origin.

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Citations

Jan 1, 1984·Histochemistry·K SchwechheimerP Möller
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·P SlootwegF Ramaekers
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·M Moorghen, F Carpenter
Mar 1, 1984·Journal of the Neurological Sciences·K SchwechheimerP Möller
Jun 1, 1994·Journal of Neurosurgery·C LafitteM Jan
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T Ehara, T Katsuyama
Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H NishiokaA Hirano
Jul 8, 2000·Pathology International·S KasashimaI Nakanishi
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·W B Nathrath, K Remberger
Dec 1, 1995·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·E KaiserlingJ C Xiao

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