PMID: 16643721Apr 29, 2006Paper

Emphasis on the research of apoptosis in retinal degeneration diseases

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
Ying-jun Niu

Abstract

Many ocular fundus diseases such as retinitis pigmentosa and age-related macular degeneration are retinal degeneration diseases, which may lead to visual loss. The main pathologic character of such retinal degeneration diseases is apoptosis of retinal cells. In recent years, some progresses have been achieved on the prevention of apoptosis of retinal cells. In the field of ophthalmologic clinical and basic research, it is important to explore the use of anti-apoptotic approaches as novel preventive and therapeutic procedures for retinal degeneration diseases.

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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