Empirical evidence for definitions of episode, remission, recovery, relapse and recurrence in depression: a systematic review

Epidemiology and Psychiatric Sciences
P L de ZwartP de Jonge

Abstract

For the past quarter of a century, Frank et al.'s (1991) consensus-based definitions of major depressive disorder (MDD) episode, remission, recovery, relapse and recurrence have been the paramount driving forces for consistency in MDD research as well as in clinical practice. This study aims to review the evidence for the empirical validation of Frank et al.'s proposed concept definitions and to discuss evidence-based modifications. A literature search of Web of Science and PubMed from 1/1/1991 to 08/30/2017 identified all publications which referenced Frank et al.'s request for definition validation. Publications with data relevant for validation were included and checked for referencing other studies providing such data. A total of 56 studies involving 39 315 subjects were included, mainly presenting data to validate the severity and duration thresholds for defining remission and recovery. Most studies indicated that the severity threshold for defining remission should decrease. Additionally, specific duration thresholds to separate remission from recovery did not add any predictive value to the notion that increased remission duration alleviates the risk of reoccurrence of depressive symptoms. Only limited data were availabl...Continue Reading

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Citations

Aug 30, 2018·BMJ Evidence-based Medicine·Michael P Hengartner
Aug 31, 2019·The International Journal of Eating Disorders·Tracey D Wade, James Lock
Feb 8, 2020·The International Journal of Eating Disorders·Joanna E SteinglassEvelyn Attia
Feb 29, 2020·The International Journal of Eating Disorders·Kyle P De YoungKamryn T Eddy
Sep 16, 2020·Journal of Dental Education·Francisco Wilker M G MunizMaísa Casarin
May 19, 2020·Annals of Internal Medicine·Jeffrey L Jackson
Jul 19, 2020·International Journal of Environmental Research and Public Health·Fakhar ShahzadMuhammad Umair Wattoo
Jan 11, 2021·Journal of Affective Disorders·Sneha ChenjiFrank P MacMaster
Mar 5, 2021·Osong Public Health and Research Perspectives·Baksun Sung
Mar 13, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hui-Qin WangNai-Hong Chen
Jun 23, 2021·The American Journal of Psychiatry·B Timothy WalshAllan S Kaplan
Aug 20, 2021·Health & Social Care in the Community·Monique PhippsMichelle Cleary

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