Empirical modelling to predict the refractive index of human blood

Physics in Medicine and Biology
M Yahya, M Z Saghir

Abstract

Optical techniques used for the measurement of the optical properties of blood are of great interest in clinical diagnostics. Blood analysis is a routine procedure used in medical diagnostics to confirm a patient's condition. Measuring the optical properties of blood is difficult due to the non-homogenous nature of the blood itself. In addition, there is a lot of variation in the refractive indices reported in the literature. These are the reasons that motivated the researchers to develop a mathematical model that can be used to predict the refractive index of human blood as a function of concentration, temperature and wavelength. The experimental measurements were conducted on mimicking phantom hemoglobin samples using the Abbemat Refractometer. The results analysis revealed a linear relationship between the refractive index and concentration as well as temperature, and a non-linear relationship between refractive index and wavelength. These results are in agreement with those found in the literature. In addition, a new formula was developed based on empirical modelling which suggests that temperature and wavelength coefficients be added to the Barer formula. The verification of this correlation confirmed its ability to determ...Continue Reading

References

Aug 25, 2004·Physical Review Letters·Dirk J FaberTon G van Leeuwen
Oct 5, 2006·Physics in Medicine and Biology·Y L JinP N Wang
Feb 28, 2008·Applied Optics·M HammerA Kolb
May 1, 1948·Journal of the Optical Society of America·P KUBELKA
Jun 17, 2011·Physics in Medicine and Biology·O ZhernovayaA Douplik
May 15, 2013·Physics in Medicine and Biology·Steven L Jacques

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Citations

Mar 17, 2018·Journal of Biomedical Optics·Ekaterina N Lazareva, Valery V Tuchin
Aug 25, 2018·Journal of Biomedical Optics·Alexey N BashkatovValery V Tuchin
May 6, 2019·Journal of Biophotonics·Muhannad N FadhelMichael C Kolios

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