Empirical power and sample size calculations for cluster-randomized and cluster-randomized crossover studies.

PloS One
Nicholas G ReichTrish M Perl

Abstract

In recent years, the number of studies using a cluster-randomized design has grown dramatically. In addition, the cluster-randomized crossover design has been touted as a methodological advance that can increase efficiency of cluster-randomized studies in certain situations. While the cluster-randomized crossover trial has become a popular tool, standards of design, analysis, reporting and implementation have not been established for this emergent design. We address one particular aspect of cluster-randomized and cluster-randomized crossover trial design: estimating statistical power. We present a general framework for estimating power via simulation in cluster-randomized studies with or without one or more crossover periods. We have implemented this framework in the clusterPower software package for R, freely available online from the Comprehensive R Archive Network. Our simulation framework is easy to implement and users may customize the methods used for data analysis. We give four examples of using the software in practice. The clusterPower package could play an important role in the design of future cluster-randomized and cluster-randomized crossover studies. This work is the first to establish a universal method for calcu...Continue Reading

Associated Clinical Trials

References

May 26, 1999·International Journal of Epidemiology·R J Hayes, S Bennett
May 15, 2003·Journal of the Royal Army Medical Corps·A J GibbonsS J Key
Mar 16, 2006·Statistics in Medicine·Rebecca M TurnerUNKNOWN PIP Study Group
Nov 18, 2006·Contemporary Clinical Trials·Jean-Jacques Parienti, Oliver Kuss
Jul 23, 2008·Statistics in Medicine·B GiraudeauA Donner
Apr 5, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Andrew LeeAaron M Milstone

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Citations

Jul 2, 2014·PloS One·Alan Vázquez-AlcocerRosa María Sánchez-Casas
Sep 28, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jessina C McGregor, Jon P Furuno
Nov 3, 2015·Seminars in Fetal & Neonatal Medicine·William Tarnow-MordiJonathan Morris
Jul 16, 2015·International Journal of Epidemiology·Clare RutterfordSandra Eldridge
Jan 21, 2016·Annual Review of Public Health·Catherine M Crespi
Apr 19, 2015·BMC Medical Research Methodology·Hanna Oltean, Joel J Gagnier
Jun 9, 2016·Trials·Mariabeth SilkeyThomas A Smith
Mar 22, 2014·Clinical Trials : Journal of the Society for Clinical Trials·Rui WangVictor De Gruttola
Mar 5, 2016·Clinical Trials : Journal of the Society for Clinical Trials·Monica TaljaardDean A Fergusson
Aug 11, 2018·Science·Jason N DoctorMichael Menchine
Apr 8, 2020·JAMA Network Open·UNKNOWN Program of Randomized Trials to Evaluate Pre-operative Antiseptic Skin Solutions in Orthopaedic Trauma (PREP-IT) InvestigatoUyen Nguyen
Dec 6, 2014·Clinical Trials : Journal of the Society for Clinical Trials·Andrew B ForbesRinaldo Bellomo
May 3, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Lyndsay M O'HaraUNKNOWN CDC Prevention Epicenters Program
Oct 8, 2020·International Journal of Audiology·Rik CrutzenGjalt-Jorn Ygram Peters
Dec 4, 2020·Statistical Methods in Medical Research·Duncan T WilsonRebecca Ea Walwyn

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Software Mentioned

crxo
SAS
clusterPower R Archive Network (
clusterPower
clusterPower package for
cr
R
clusterPower package
exD
STATA

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