Empirical treatment of granulomatous hepatitis of unknown origin: practice investigation in the French National Society of Internal Medicine

La Revue de médecine interne
C AgardJ-H Barrier

Abstract

Ten to fifteen percent of granulomatous hepatitis are idiopathic. If symptoms like prolonged fever are present, empirical treatment is discussed. The goal of this study is to describe the empirical treatment proposed in this situation by French specialists of internal medicine. We conducted a practice investigation among the French national society of internal medicine (SNFMI), using an anonymous questionnaire that related a case of idiopathic granulomatous hepatitis. This questionnaire was proposed to all French internists present at the SNFMI congress in June and December 2004. French specialists of internal medicine had to answer if they would prescribe an empirical treatment and if so, to specify this treatment. Thirty-six French specialists of internal medicine answered to the questionnaire. In the proposed situation, 89% of them initiate an empirical treatment. In 18/36 cases (50%), a first-line anti-tuberculosis empirical treatment is proposed (quadritherapy in 11 cases). In 7 cases (19%), an empirical treatment with prednisone, 0.4 mg/kg/d (N=1) and 1 mg/kg/d (N=6), would be prescribed. Seven internists (19%) would prescribe an empirical treatment with cyclins at the dose of 100 to 400 mg/d. Median duration of the empir...Continue Reading

References

Jan 1, 1992·Archives of Internal Medicine·D C KnockaertH J Bobbaers
May 1, 1989·Mayo Clinic Proceedings·T V Colby
Sep 1, 1994·Histopathology·W G McCluggage, J M Sloan
Apr 15, 1995·Annals of Internal Medicine·T A KnoxS M Wolff
Jun 1, 1997·Journal of Clinical Gastroenterology·B KnobelL Zaidel
Dec 20, 2000·The Journal of Infection·J CollazosE Martínez
Feb 15, 2001·Archives of Dermatology·H BachelezL Dubertret
Mar 10, 2001·Clinics in Liver Disease·D C Valla, J P Benhamou
Jul 13, 2004·Autoimmunity Reviews·Trevor G Marshall, Frances E Marshall

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Citations

Jan 22, 2008·La Revue de médecine interne·J SerratriceP J Weiller
Jun 2, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Gian Luca GraziAntonio Daniele Pinna
Sep 14, 2010·La Revue de médecine interne·G Geri, P Cacoub

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