Employing Conductive Metal-Organic Frameworks for Voltammetric Detection of Neurochemicals.

Journal of the American Chemical Society
Michael KoKatherine A Mirica

Abstract

This paper describes the first implementation of an array of two-dimensional (2D) layered conductive metal-organic frameworks (MOFs) as drop-casted film electrodes that facilitate voltammetric detection of redox active neurochemicals in a multianalyte solution. The device configuration comprises a glassy carbon electrode modified with a film of conductive MOF (M3HXTP2; M = Ni, Cu; and X = NH, 2,3,6,7,10,11-hexaiminotriphenylene (HITP) or O, 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP)). The utility of 2D MOFs in voltammetric sensing is measured by the detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), and serotonin (5-HT) in 0.1 M PBS (pH = 7.4). In particular, Ni3HHTP2 MOFs demonstrated nanomolar detection limits of 63 ± 11 nM for DA and 40 ± 17 nM for 5-HT through a wide concentration range (40 nM-200 μM). The applicability in biologically relevant detection was further demonstrated in simulated urine using Ni3HHTP2 MOFs for the detection of 5-HT with a nanomolar detection limit of 63 ± 11 nM for 5-HT through a wide concentration range (63 nM-200 μM) in the presence of a constant background of DA. The implementation of conductive MOFs in voltammetric detection holds promise for further development of highly modul...Continue Reading

References

Mar 1, 1985·Metabolism: Clinical and Experimental·J M Feldman
Jul 1, 1965·Biochemistry·W A Struck, P J Elving
Oct 1, 1983·Brain Research·R J Beninger
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein
Mar 14, 1997·Science·W SchultzP R Montague
Mar 1, 1997·Letters in Applied Microbiology·T Brooks, C W Keevil
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·D J Michael, R M Wightman
Apr 27, 2000·Trends in Neurosciences·M E Rice
Dec 18, 2002·Accounts of Chemical Research·J-C Charlier
Jun 13, 2003·Nature·Omar M YaghiJaheon Kim
Apr 15, 2004·Analytical Chemistry·Dimitrios P NikolelisSpyros Koinis
Sep 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Qi ChenMark Levine
May 4, 2006·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Xiaobo JiRichard G Compton
Apr 7, 2007·European Journal of Endocrinology·Rosario PivonelloLeo J Hofland
Jun 19, 2008·Chemical Reviews·Richard L McCreery
Jun 26, 2008·Chemical Reviews·Donita L RobinsonR Mark Wightman
Jan 9, 2010·Analytical Chemistry·John NjagiSilvana Andreescu
Feb 27, 2010·Angewandte Chemie·Wenrong YangFilip Braet
May 27, 2010·Chemical Society Reviews·Benjamin J PrivettMark H Schoenfisch
Apr 7, 2011·Methods in Molecular Biology·Hsin-Yao TangDavid W Speicher
Dec 14, 2011·Analytical and Bioanalytical Chemistry·Mikaela I NichkovaGottfried H Kellermann
Feb 22, 2012·Biosensors & Bioelectronics·Li WuXiaogang Qu

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Citations

Sep 16, 2020·Chemical Communications : Chem Comm·Wei Huan HoChung-Wei Kung
Dec 18, 2020·Chemical Communications : Chem Comm·Mohammad R MomeniFarnaz A Shakib
Jan 12, 2021·Frontiers in Chemistry·Jing WangChuanxiang Zhang
Jan 8, 2021·ACS Applied Materials & Interfaces·Nako NakatsukaAnne M Andrews
Feb 26, 2021·Journal of Colloid and Interface Science·Khaled M AminWolfgang Ensinger
Mar 9, 2021·Coordination Chemistry Reviews·Xuan ZhangOmar K Farha
May 19, 2021·Journal of the American Chemical Society·David L WhiteAlexander Star
Apr 16, 2021·Chemistry : a European Journal·Akashdeep NathSukhendu Mandal
Dec 15, 2020·Journal of the American Chemical Society·Gan ChenZhenan Bao

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