Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

Materials Science & Engineering. C, Materials for Biological Applications
Dnyaneshwar KalyaneRakesh K Tekade

Abstract

In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers great opportunity to treat cancer and the phenomenon is known as Enhanced permeability and retention (EPR) effect. The trends in treating cancer by making use of EPR effect is increasing day by day and generate multitudes of possibility to design novel anticancer therapeutics. This review aimed to present various factors affecting the EPR effect along with important things to know about EPR effect such as tumor perfusion, lymphatic function, interstitial penetration, vascular permeability, nanoparticle retention etc. This manuscript expounds the current advances and cross-talks the developments made in the of EPR effect-based therapeutics in cancer therapy along with a transactional view of its current clinical and industrial aspects.

Citations

Sep 19, 2019·Advanced Materials·Phuong H L TranWei Duan
Oct 3, 2019·Biomaterials Science·Zhengkui ZhangXiqun Jiang
Nov 30, 2019·The Analyst·Huili LiAjun Wan
Dec 19, 2019·Journal of Clinical Medicine·Zahraa YoussefCéline Frochot
Mar 11, 2020·Pharmaceutics·Catarina Roma-RodriguesAlexandra R Fernandes
Nov 21, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ye-Juan ZhouXue-Nong Zhang
Jun 25, 2020·Small·Hèctor López-LagunaEsther Vázquez
Jun 27, 2020·Pharmaceutical Development and Technology·Sun YushengZhang Liefeng
May 28, 2020·Science China. Life Sciences·Xiaoyu WangChunying Chen
Aug 1, 2020·Journal of Cellular Physiology·Taranom MobasheriNima Rezaei
May 8, 2020·Journal of Nanobiotechnology·Yang ZhangYong Chen
Jul 10, 2020·Journal of Biomaterials Science. Polymer Edition·Bo LiYanhai Li
Sep 5, 2019·Current Pharmaceutical Design·Sajjad Molavipordanjani, Seyed Jalal Hosseinimehr
Sep 29, 2020·International Journal of Nanomedicine·Yanan LiYan Shen
Aug 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yan GaoChongshen Guo
May 20, 2020·International Journal of Nanomedicine·Weiwei WangLingling Shan
Sep 15, 2020·International Journal of Nanomedicine·Ting HuyanQi Li
Sep 26, 2020·Frontiers in Molecular Biosciences·Yihan YaoAnwen Shao
Sep 2, 2020·Materials·Daohe YuanJason J Davis
Oct 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dusica MaysingerAshok Kakkar
Nov 13, 2020·Frontiers in Oncology·Bolun JiangJunchao Guo
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ruijiang LiuRongzhu Lu
Feb 12, 2021·International Journal of Molecular Sciences·Sylwia Cyboran-MikołajczykMagdalena Wawrzyńska
Oct 30, 2020·International Journal of Nanomedicine·Wisam Nabeel IbrahimAbd Almonem Doolaanea

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved