Empty follicle syndrome: successful treatment in a recurrent case and review of the literature

Human Reproduction
R Beck-FruchterE Shalev

Abstract

Empty follicle syndrome is a condition in which no oocytes are retrieved after an apparently adequate ovarian response to stimulation and meticulous follicular aspiration. It is a rare condition of obscure etiology. A patient with primary infertility who underwent seven assisted reproductive technique cycles is described. In spite of a satisfactory ovarian response, aspiration yielded no oocytes in four cycles and 1-4 low quality oocytes in three cycles. In the index treatment cycle, ovulation was triggered using GnRH agonist 40 h prior to ovum pickup and hCG was added 6 h after the first trigger. Eighteen oocytes were recovered, of which 16 were mature and were inseminated by ICSI. Two embryos were transferred 48 h after aspiration and nine embryos were cryopreserved. The patient conceived and delivered a healthy boy at 38 weeks of gestation. The literature is reviewed and possible etiologies and treatment options of this enigmatic syndrome are suggested.

References

Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·Y GonenR F Casper
Jun 1, 1987·Fertility and Sterility
Dec 1, 1986·Fertility and Sterility·C B CoulamJ D Schulman
Oct 1, 1983·The Journal of Clinical Endocrinology and Metabolism·J D HoffS S Yen
Mar 1, 1982·American Journal of Obstetrics and Gynecology·M M SeibelM L Taymor
May 1, 1993·Fertility and Sterility·R GrebT Bauer
Mar 1, 1997·Molecular Reproduction and Development·A G ByskovX Guoliang
Jan 1, 1997·Human Reproduction·G NdukweS Green
Jul 1, 1997·Human Reproduction·Y Khalaf, P Braude
Feb 11, 1998·Fertility and Sterility·H A HassanI Ismaiel
Mar 25, 1998·Human Reproduction·G L DriscollJ Bernstein
Jul 13, 1999·Human Reproduction·I O EvbuomwanA P Murdoch
Feb 26, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A Z Işik, K Vicdan
Apr 28, 2000·Human Reproduction·T G ZreikE E Jones
Aug 10, 2001·Journal of Assisted Reproduction and Genetics·A A Milki, S B Mooney
Aug 19, 2003·Human Reproduction·Gögsen OnalanBelgin Selam
Oct 9, 2003·Journal of Assisted Reproduction and Genetics·D UygurS Batuoğlu
Feb 5, 2004·Reproductive Biomedicine Online·María Bustillo
May 8, 2004·Journal of Endocrinological Investigation·A KourtisD Panidis
Dec 20, 2005·Fertility and Sterility·Mustafa AktasDiederick de Jong
Sep 30, 2006·Reproductive Biomedicine Online·Mehmet Sait InanSerdar Coskun
Nov 21, 2007·Fertility and Sterility·Tania Luisa Stevenson, Hany Lashen
Feb 19, 2008·Fertility and Sterility·Arne M van HeusdenDiederick de Jong
Jul 1, 2008·The Journal of Obstetrics and Gynaecology Research·Hussein QublanAnwar Al-Masri
Jan 29, 2009·Human Reproduction·N DesaiT Falcone
Jun 30, 2009·Journal of Human Reproductive Sciences·Deepika KrishnaMadhuri Patil
Nov 17, 2009·Fertility and Sterility·David E ReichmanCatherine Racowsky
Mar 4, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Serdar CoskunKhalid Awartani

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Citations

Nov 12, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Eran ZilberbergRaoul Orvieto
Mar 24, 2016·Reproductive Biology and Endocrinology : RB&E·A WeissE Shalev
Aug 22, 2015·Journal of Ovarian Research·Raoul Orvieto
Nov 21, 2015·Journal of Ovarian Research·Stefano PalombaGiovanni Battista La Sala
Nov 6, 2015·Journal of Human Reproductive Sciences·K DeepikaKamini Rao
Jul 26, 2015·Reproductive Biology and Endocrinology : RB&E·John Zhang
Aug 3, 2014·Human Reproduction·Anna BlazquezValerie Vernaeve
Mar 19, 2013·Reproductive Biomedicine Online·Bin Xu, Yanping Li
Jan 25, 2013·Clinical and Experimental Reproductive Medicine·Jee Hyun Kim, Byung Chul Jee
Jun 9, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Miro KasumLana Škrgatić
Jul 10, 2018·Endocrine Reviews·Ali AbbaraWaljit S Dhillo
Aug 30, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vandana Mishra, Lakshmi Chirumamilla
Jan 25, 2019·Panminerva Medica·Carlos DosoutoPeter Humaidan
Feb 28, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jigal HaasRaoul Orvieto
Jun 29, 2017·Journal of Assisted Reproduction and Genetics·Raoul Orvieto
Mar 27, 2020·Upsala Journal of Medical Sciences·Juan Carlos CastilloPeter Humaidan
May 18, 2017·International Journal of Molecular Sciences·Anat Hershko Klement, Adrian Shulman
Feb 20, 2019·Journal of Assisted Reproduction and Genetics·Ping YuanWenjun Wang
Oct 2, 2019·Frontiers in Endocrinology·Thor HaahrPeter Humaidan
Mar 25, 2020·International Journal of Molecular Sciences·Antoine Abu-MusaPeter Humaidan
Dec 18, 2020·Human Fertility : Journal of the British Fertility Society·Anat Hershko KlementAdrian Shulman
Mar 6, 2021·Journal of Assisted Reproduction and Genetics·Jing WangXiang Ma
Jun 5, 2021·Journal of Human Reproductive Sciences·Abdul Majiyd NoushinMohamed Ashraf

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