eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54

Multiple Sclerosis : Clinical and Laboratory Research
Rosalba RosatoAlessandra Solari

Abstract

We recently devised a shortened version of the 54-item Multiple Sclerosis Quality of Life (MSQOL-54) in paper (MSQOL-29, consisting of 25 items forming 7 subscales and 4 single items, and one filter question for 3 'sexual function' items) and electronic format (eMSQOL-29). To prospectively assess eMSQOL-29 psychometric properties, acceptability/equivalence versus MSQOL-29. Multiple sclerosis (MS) patients ( n = 623; Expanded Disability Status Scale (EDSS) range 0.0-9.0) completed eMSQOL-29, Hospital Anxiety and Depression Scale, Functional Assessment of MS (FAMS), European Quality of life Five Dimensions-3L, and received EDSS and Symbol Digit Modalities Test (SDMT). Equivalence versus MSQOL-29 was assessed in 242 patients (randomized cross-over design). 'Sexual function' items were filtered out by 273 patients (47%). No multi-item scale had floor effect, while five had ceiling effect. Cronbach's alpha range was 0.88-0.90. Confirmatory factor analysis showed good overall fit and the two-factor solution for composite scores was confirmed. Criterion validity was sub-optimal for 'cognitive function' (vs SDMT, r = 0.25) and 'social function' (vs FAMS social function, r = 0.38). eMSQOL-29 equivalence was confirmed and its acceptabili...Continue Reading

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Citations

Nov 11, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Andrea GiordanoRosalba Rosato
Jan 29, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Giovanni SellittoAnna Berardi

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Software Mentioned

eMSQOL
LISREL
SAS

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