EMT is associated with an epigenetic signature of ECM remodeling genes

Cell Death & Disease
Paul PeixotoEric Hervouet

Abstract

Type III epithelial-mesenchymal transition (EMT) has been previously associated with increased cell migration, invasion, metastasis, and therefore cancer aggressiveness. This reversible process is associated with an important gene expression reprogramming mainly due to epigenetic plasticity. Nevertheless, most of the studies describing the central role of epigenetic modifications during EMT were performed in a single-cell model and using only one mode of EMT induction. In our study, we studied the overall modulations of gene expression and epigenetic modifications in four different EMT-induced cell models issued from different tissues and using different inducers of EMT. Pangenomic analysis (transcriptome and ChIP-sequencing) validated our hypothesis that gene expression reprogramming during EMT is largely regulated by epigenetic modifications of a wide range of genes. Indeed, our results confirmed that each EMT model is unique and can be associated with a specific transcriptome profile and epigenetic program. However, we could select some genes or pathways that are similarly regulated in the different models and that could therefore be used as a common signature of all EMT models and become new biomarkers of the EMT phenotype....Continue Reading

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Citations

Dec 5, 2019·Clinical and Experimental Pharmacology & Physiology·Ning LiuYu-Sheng Cong
Jul 7, 2020·Frontiers in Pharmacology·Shihori TanabeRyuichi Ono
May 3, 2020·Nature Communications·David P Cook, Barbara C Vanderhyden
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Jan 6, 2022·Science Advances·David P Cook, Barbara C Vanderhyden

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Datasets Mentioned

BETA
GSE6532
GSE77803

Methods Mentioned

BETA
immunoprecipitation
flow cytometry
enzyme-linked immunosorbent assay
acetylation
flow
ChIP-seq
ChIP
PCR
Protein Assay
Assay

Software Mentioned

primer
BETA
kmplot
GraphPad Prism5
ArrayExpress
ImageJ
GeneSpring GX
basic
genefu R
BWA

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