PMID: 9416725Jan 7, 1998Paper

Emulsion formulation reduces propofol's dose requirements and enhances safety

Anesthesiology
S Dutta, W F Ebling

Abstract

Propofol, a highly lipophilic anesthetic, is formulated in a lipid emulsion for intravenous use. Propofol has brisk onset and offset of effect after rapid administration and retains rapid offset characteristics after long-term administration. The authors tried to determine whether the emulsion vehicle is requisite for propofol's evanescent effect-time profile. The time course of sedation and electroencephalographic (EEG) effect after propofol administration was measured in three studies in rats instrumented. In study 1, propofol was infused in either emulsion or lipid-free vehicle (n = 12), in a repeated measures cross-over design. In study 2, propofol in lipid-free vehicle was infused with or without simultaneous infusion of drug-free lipid emulsion (n = 6) in a repeated measures cross-over design. In study 3, propofol was infused in either emulsion (n = 5) or lipid-free vehicle (n = 5) to EEG burst suppression. In study 1, relative to the emulsion formulation, propofol administered at equivalent doses in lipid-free vehicle resulted in a longer time to effect onset (1.4 +/- 0.2 vs. 0.5 +/- 0.1 min, EEG) and a trend for delayed anesthetic recovery (26.8 +/- 9.4 vs. 17 +/- 3.5 min, EEG; 26.1 +/- 8.8 vs. 16.8 +/- 3.3 min, sleep)....Continue Reading

References

Jan 1, 1976·Acta Anaesthesiologica Scandinavica·O von DardelT Mossberg
Apr 1, 1992·Anaesthesia·R S Clarke
Oct 1, 1991·Journal of Pharmacobio-dynamics·K UmezawaS Awazu
Sep 1, 1991·British Journal of Anaesthesia·W Klement, J O Arndt
Aug 1, 1991·Biopharmaceutics & Drug Disposition·A K Shah, R J Sawchuk
Apr 1, 1991·Journal of Pharmacokinetics and Biopharmaceutics·W F EblingD R Stanski
Oct 1, 1988·British Journal of Anaesthesia·K TaegerK Peter
Oct 1, 1987·Anesthesiology·D L RoerigJ P Kampine
Jan 1, 1966·Acta Pharmacologica Et Toxicologica·G Wahlström
Jun 1, 1984·British Journal of Anaesthesia·J B Glen, S C Hunter
Feb 1, 1996·Anesthesiology·L L GustafssonD R Stanski
Jan 1, 1997·Journal of Pharmaceutical Sciences·S DuttaW F Ebling

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Citations

Aug 1, 1997·Journal of Pharmaceutical Sciences·S DuttaW F Ebling
Aug 19, 2004·Acta Anaesthesiologica Scandinavica·R CalvoJ C Lukas
Jul 28, 2004·Neuropharmacology·Henry WeigtKarl J Föhr
May 30, 2015·Journal of Translational Medicine·Krystyna M WozniakBarbara S Slusher
Mar 14, 2001·Critical Care Medicine·R Barrientos-VegaM Castellano-Hernández
Apr 20, 2005·Pharmaceutical Research·Hongming ChenColin R Gardner
Jan 29, 2002·Anesthesia and Analgesia·Henry U WeigtKarl J Föhr
Oct 7, 2019·Journal of Biomedical Materials Research. Part a·Elton B RibeiroMaria A G Soler
Oct 4, 2011·Anesthesia and Analgesia·Ervin PejoDouglas E Raines
Jan 22, 2014·Toxicology and Industrial Health·Mohammad MoshiriHossein Hosseinzadeh
Sep 30, 2005·Anesthesiology·Max T Baker, Mohamed Naguib
Mar 21, 1998·The Journal of Pharmacy and Pharmacology·S Dutta, W F Ebling

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