Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product?

Drug Delivery and Translational Research
Umberto M MusazziAntonella Casiraghi

Abstract

The use of nanoemulsions in cosmetic products has been enlarged in the last decades because of several formulative advantages (e.g., the improved self-life stability, better texture properties). In addition, nanoemulsions seemed to improve the penetration of active ingredients through the human skin, comparing to conventional emulsion. In this contest, the risk of a higher systemic exposure of consumer to active ingredients, due to the ability of nanoemulsion to enhance permeation, results a critical attribute that should be evaluated for assuring the consumer safety. The aim of this work was the evaluation of how an oil-in-water (O/W) nanoemulsion can influence the in vitro skin permeation profiles of two model active ingredients with different polarity (i.e., caffeine and ethyl ximenynate). Preliminarily, since both selected molecules influenced the physical stability of nanoemulsion, formulative studies were carried out to identify the most stable formulation to perform in vitro permeation studies. The overall results demonstrated that nanoemulsions could significantly influence the permeation profiles of molecules as a function of their physicochemical properties. In particular, O/W nanoemulsions significantly improved the ...Continue Reading

References

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May 3, 2015·International Journal of Pharmaceutics·Umberto M MusazziPaola Minghetti
Jun 24, 2015·Drug Discovery Today·Abdul AhadFahad I Al-Jenoobi
Jul 15, 2015·International Journal of Cosmetic Science·M N YukuyamaN A Bou-Chacra
Aug 18, 2016·Skin Pharmacology and Physiology·Antonella CasiraghiPaola Minghetti

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Citations

Dec 6, 2017·Drug Delivery and Translational Research·Vivek Agrahari
Aug 8, 2020·Environmental Science and Pollution Research International·Nimmy Kumar, Jobin Jose
May 24, 2020·Nanomaterials·Georgios FytianosGeorge Z Kyzas
Feb 3, 2021·Nanomaterials·Noriyuki UchidaHiroki Hamada
Jul 10, 2021·PloS One·Alex Bruno Lobato RodriguesSheylla Susan Moreira da Silva de Almeida

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BETA
light scattering
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Excel

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