PMID: 9645544Jun 30, 1998Paper

En bloc staining of bone under load does not improve dye diffusion into microcracks

Journal of Biomechanics
D B BurrR Pidaparti

Abstract

Microdamage accumulation in bone has been implicated in the pathogenesis of some bone fractures, and in implant loosening. Standard techniques for staining microcracks may not allow all cracks to be stained. We tested the hypothesis that crack closure in bone cortices after removal of a bending load may prevent diffusion of stain to sites of microcrack nucleation. Following cyclic loading, 26 canine femurs were divided into a group stained en bloc while applying a four point bending load, and another group stained without an applied load. No differences in number or length of microcracks were observed, indicating that crack closure does not prevent diffusion of stain to the crack location. Staining under load is unnecessary.

References

Jul 1, 1989·Calcified Tissue International·M R Forwood, A W Parker
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Mar 29, 1995·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P ZiouposD C Barton
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Sep 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R B MartinL V Griffin

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Citations

Jun 20, 2002·Journal of Biomechanical Engineering·S Ramtani, M Zidi
Oct 11, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Lei WangShijing Qiu

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