En passant neurotrophic action of an intermediate axonal target in the developing mammalian CNS

Nature
H Wang, M Tessier-Lavigne

Abstract

During development, neurons extend axons to their targets, then become dependent for their survival on trophic substances secreted by their target cells. Competition for limiting amounts of these substances is thought to account for much of the extensive naturally-occurring cell death that is seen throughout the nervous system. Here we show that spinal commissural neurons, a group of long projection neurons in the central nervous system (CNS), are also dependent for their survival on trophic support from one of their intermediate targets, the floor plate of the spinal cord. This dependence occurs during a several-day-long period when their axons extend along the floor plate, following which they develop additional trophic requirements. A dependence of neurons on trophic support derived en passant from their intermediate axonal targets provides a mechanism for rapidly eliminating misprojecting neurons, which may help to prevent the formation of aberrant neuronal circuits during the development of the nervous system.

References

Oct 18, 1996·Cell·K Keino-MasuM Tessier-Lavigne
Feb 1, 1997·Current Opinion in Neurobiology·A M Davies
May 15, 1998·Neuron·B Pettmann, C E Henderson

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Citations

May 29, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Z KaprielianR Imondi
Feb 20, 2009·Nature·Anatoly NikolaevMarc Tessier-Lavigne
Mar 21, 2009·Nature Reviews. Neuroscience·Daniel L ChaoKang Shen
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May 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cyril DrayFranck Debarbieux
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Nov 1, 2001·Nature Neuroscience·T W Gould, R W Oppenheim
Jun 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alan G Porter, Saravanakumar Dhakshinamoorthy
Nov 5, 1999·Nature·J G Flanagan
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Jun 22, 2000·The Journal of Comparative Neurology·R S DammermanA R Kriegstein
Oct 21, 2018·Journal of Developmental Biology·Riley KellermeyerThomas Kidd
Oct 4, 2002·Current Biology : CB·Barry Condron
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Feb 20, 2004·Development·Jessica A CouchBarry G Condron
Mar 14, 2001·Science·B J Dickson
Apr 22, 2003·Genes & Development·Jeffrey L Goldberg

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