En1 and Wnt signaling in midbrain dopaminergic neuronal development.

Neural Development
Maria T M Alves dos Santos, Marten P Smidt

Abstract

Dopaminergic neurons of the ventral mesodiencephalon are affected in significant health disorders such as Parkinson's disease, schizophrenia, and addiction. The ultimate goal of current research endeavors is to improve the clinical treatment of such disorders, such as providing a protocol for cell replacement therapy in Parkinson's disease that will successfully promote the specific differentiation of a stem cell into a dopaminergic neuronal phenotype. Decades of research on the developmental mechanisms of the mesodiencephalic dopaminergic (mdDA) system have led to the identification of many signaling pathways and transcription factors critical in its development. The unraveling of these pathways will help fill in the pieces of the puzzle that today dominates neurodevelopment research: how to make and maintain a mdDA neuron. In the present review, we provide an overview of the mdDA system, the processes and signaling molecules involved in its genesis, with a focus on the transcription factor En1 and the canonical Wnt pathway, highlighting recent findings on their relevance--and interplay--in the development and maintenance of the mdDA system.

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Citations

Sep 28, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kimberly A Mulligan, Benjamin N R Cheyette
Jul 30, 2014·Cellular and Molecular Life Sciences : CMLS·Jesse V Veenvliet, Marten P Smidt
Jan 19, 2012·Expert Opinion on Therapeutic Patents·Valerio ChiurchiùAntonio Orlacchio
Sep 30, 2014·Neuroscience and Biobehavioral Reviews·Syed Mohammed Qasim HussainiMi-Hyeon Jang
Jun 20, 2012·The European Journal of Neuroscience·Julia FuchsRajiv L Joshi
May 20, 2015·Reproductive Toxicology·Jennifer Z J MaccaniKarl T Kelsey
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Jul 20, 2014·Neuropsychologia·Polina ZozulinskyRachel Tomer
Jul 28, 2016·Neuroscience·Renata A N PertileDarryl W Eyles
Oct 12, 2013·Journal of Molecular Cell Biology·Daniel C Berwick, Kirsten Harvey
Oct 12, 2019·Experimental and Therapeutic Medicine·Cui HuangYan Sun
Nov 30, 2013·Journal of Molecular Cell Biology·Milan Joksimovic, Rajeshwar Awatramani
Aug 2, 2018·Physiological Reviews·Ariel A Di NardoAlain Prochiantz
Jul 17, 2020·Frontiers in Neuroscience·Nobuyuki EuraEiichiro Mori
Jul 30, 2021·Nature·Gioele La MannoSten Linnarsson
Nov 2, 2021·Frontiers in Cell and Developmental Biology·Verónica CompanyEduardo Puelles

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Methods Mentioned

BETA
ubiquitination
nuclear translocation
immunoprecipitation

Software Mentioned

mdDA

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