Enabling direct fate conversion with network biology

Nature Genetics
Patrick Cahan

Abstract

Current efforts in cellular disease modeling and regenerative medicine are limited by the paucity of cell types that can be generated in the laboratory. A new study introduces a computational framework, Mogrify, that uses network biology to predict combinations of transcription factors necessary for direct conversion between human cell types to ameliorate this issue.

References

Jul 17, 2012·Nature Methods·Daniel MarbachGustavo Stolovitzky
Mar 29, 2014·Nature·UNKNOWN FANTOM Consortium and the RIKEN PMI and CLST (DGT)Yoshihide Hayashizaki
Jul 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Victor C Li, Marc W Kirschner
Aug 16, 2014·Cell·Patrick CahanJames J Collins
Jan 19, 2016·Nature Genetics·Owen J L RackhamJulian Gough

❮ Previous
Next ❯

Citations

Dec 9, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Gabrielle A DotsonIndika Rajapakse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.