Enabling sublingual peptide immunization with molecular self-assemblies.

Biomaterials
Sean H KellyJoel H Collier

Abstract

Short peptides are poorly immunogenic when delivered sublingually - under the tongue. Nanomaterial delivery of peptides could be utilized to improve immunogenicity towards designed sublingual vaccines, but nanomaterials have not been widely successful in sublingual vaccines owing to the challenges of transport through the sublingual mucosa. Here, we report that the sublingual immunogenicity of peptides is negligible, even in the presence of sublingual adjuvants or when PEGylated, but can be dramatically enhanced by assembly into supramolecular polymer-peptide nanofibers bearing low-molecular weight PEG, optimally between 2000 and 3000 Da. Neither PEGylation nor a sublingual adjuvant were capable of rendering peptides immunogenic without assembly into nanofibers. We found that PEG decreased nanofiber interactions with mucin and promoted longer residence time at the sublingual immunization site. Parallel investigations with shortened nanofibers indicated that the size of the assemblies had a surprisingly negligible influence over sublingual immunogenicity. In mice, optimized formulations were capable of raising strong and highly durable systemic antibody responses, antibodies in the upper respiratory and reproductive tracts, and ...Continue Reading

References

Nov 1, 1996·European Journal of Immunology·Y CongC O Elson
Jul 17, 2003·Bioconjugate Chemistry·Joel H Collier, Phillip B Messersmith
Feb 11, 2004·International Journal of STD & AIDS·Anja M HauriYvan J F Hutin
Feb 24, 2006·Nature Reviews. Immunology·Marian R Neutra, Pamela A Kozlowski
Jan 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Samuel K LaiJustin Hanes
Oct 6, 2007·Bioconjugate Chemistry·Benedict LawChing-Hsuan Tung
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joo-Hye SongMi-Na Kweon
Mar 29, 2008·Biochemistry·Marta J KrysmannDarrin J Pochan
Jan 10, 2009·Advanced Drug Delivery Reviews·Samuel K LaiJustin Hanes
Jan 13, 2009·Advanced Drug Delivery Reviews·Richard A Cone
Jan 27, 2009·Advanced Drug Delivery Reviews·Samuel K LaiJustin Hanes
Nov 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Benjamin C TangJustin Hanes
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Samuel K LaiJustin Hanes
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jai S RudraJoel H Collier
May 11, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·V CastellettoL Noirez
Jul 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yen CuW Mark Saltzman
Aug 26, 2011·Biomacromolecules·Joshua Z Gasiorowski, Joel H Collier
Jan 26, 2012·ACS Nano·Jai S RudraJoel H Collier
Apr 25, 2012·Annual Review of Biomedical Engineering·Kim A WoodrowDavid D Lo
May 17, 2012·Journal of the American Chemical Society·Zhi-Hua HuangYan-Mei Li
Jul 26, 2012·Nature Reviews. Immunology·Nils Lycke
Nov 28, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Anil WaghBenedict Law
Jun 12, 2013·Protein Engineering, Design & Selection : PEDS·Martin SchlapschyArne Skerra
Dec 7, 2013·Vaccine·Charles B ChessonJai S Rudra
Jun 10, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Heleen KraanJean-Pierre Amorij
Jun 14, 2014·Advanced Healthcare Materials·Rebecca R PompanoAnita S Chong
Dec 21, 2014·The AAPS Journal·Amanda TrentMatthew V Tirrell
Apr 4, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Ian W HamleyJanne Ruokolainen
Oct 1, 2015·Annual Review of Biomedical Engineering·Nathan A HotalingJulia E Babensee
Nov 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hardeep S OberoiDavid J Burkhart
Nov 21, 2015·Acta Biomaterialia·Tao SunJoel H Collier
Feb 11, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Akhilesh Kumar ShakyaHarvinder Singh Gill
Jul 3, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Peng ZhangShaoyi Jiang

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Citations

Jun 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrew W SimonsonScott H Medina
Feb 27, 2021·Advanced Healthcare Materials·Sean H KellyJoel H Collier
Mar 12, 2021·Advanced Functional Materials·Shannon J TsaiChristopher M Jewell
Mar 20, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·A L ParisC Monge
Dec 17, 2020·ACS Biomaterials Science & Engineering·Benjamin CossetteJoel H Collier
Jul 31, 2021·Progress in Biophysics and Molecular Biology·Isha Bhorkar, Abhishek S Dhoble
Jul 31, 2021·Current Opinion in Chemical Biology·Tania L Lopez-Silva, Joel P Schneider

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