Enalapril in Combination with Benznidazole Reduces Cardiac Inflammation and Creatine Kinases in Mice Chronically Infected with Trypanosoma cruzi

The American Journal of Tropical Medicine and Hygiene
Arlete Rita PenitenteAndré Talvani

Abstract

The protozoan Trypanosoma cruzi triggers an inflammatory process in mammalian heart causing events such as fibrosis, changes in the architecture and functionality in this organ. Enalapril, an angiotensin II-converting enzyme inhibitor, is a drug prescribed to ameliorate this heart dysfunction, and appears to exert a potential role in immune system regulation. Our aim was to evaluate the chronic cardiac inflammatory parameters after therapeutic treatment with enalapril and benznidazole in C57BL/6 mice infected with the VL-10 strain of T. cruzi. After infection, animals were treated with oral doses of enalapril (25 mg/kg), benznidazole (100 mg/kg), or both during 30 days. Morphometric parameters and levels of chemokines (CCL2, CCL5), IL-10, creatine kinases (CKs), and C-reactive protein were evaluated in the heart and serum at the 120th day of infection. Enalapril alone or in combination with benznidazole did not change the number of circulating parasites, but reduced cardiac leukocyte recruitment and total collagen in the cardiac tissue. Interestingly, the combination therapy (enalapril/benznidazole) also reduced the levels of chemokines, CK and CK-MB, and C-reactive proteins in chronic phase. In conclusion, during the chronic e...Continue Reading

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Citations

May 25, 2016·International Journal of Antimicrobial Agents·María L SbaragliniCatalina D Alba Soto
May 17, 2018·Revista Da Sociedade Brasileira De Medicina Tropical·Cauê Benito ScarimChung Man Chin
Jul 13, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Déborah Maria Moreira da SilvaAndré Talvani
Dec 5, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Rodrigo Cunha de SousaDalmo Correia
Jun 20, 2020·The Journal of International Medical Research·Huanzhi MaWei Zhang
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May 18, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Andréa A S MendonçaRômulo D Novaes

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