Enalapril treatment corrects the reduced response to bradykinin in diabetes increasing the B2 protein expression

Peptides
Viviani Milan Ferreira RastelliZuleica Bruno Fortes

Abstract

Considering the growing importance of the interaction between components of kallikrein-kinin and renin-angiotensin systems in physiological and pathological processes, particularly in diabetes mellitus, the aim of the present study was to investigate the effect of enalapril on the reduced response of bradykinin and on the interaction between angiotensin-(1-7) (Ang-(1-7)) and bradykinin (BK), important components of these systems, in an insulin-resistance model of diabetes. For the above purpose, the response of mesenteric arterioles of anesthetized neonatal streptozotocin-induced (n-STZ) diabetic and control rats was evaluated using intravital microscopy. In n-STZ diabetic rats, enalapril treatment restored the reduced response to BK but not the potentiation of BK by Ang-(1-7) present in non-diabetic rats. The restorative effect of enalapril was observed at a dose that did not correct the altered parameters induced by diabetes such as hyperglycemia, glicosuria, insulin resistance but did reduce the high blood pressure levels of n-SZT diabetic rats. There was no difference in mRNA and protein expressions of B1 and B2 kinin receptor subtypes between n-STZ diabetic and control rats. Enalapril treatment increased the B2 kinin recep...Continue Reading

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Citations

Sep 17, 2011·Journal of Cardiovascular Pharmacology·Christiane MalfitanoMaria-Claudia Irigoyen
Feb 13, 2010·Molecular Endocrinology·Lei O LiRosalind A Coleman
Nov 26, 2011·Canadian Journal of Physiology and Pharmacology·Glaucy Rodrigues de AraujoDaniela Caldeira Costa
Aug 21, 2013·Expert Opinion on Therapeutic Targets·Nelly Blaes, Jean-Pierre Girolami
Dec 18, 2013·Cancer Letters·Patrícia L N da CostaRoger Chammas

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