PMID: 9532814Jul 1, 1997Paper

Enalaprilat in the prevention of left ventricular hypertrophy induced by isoproterenol

Arquivos brasileiros de cardiologia
E A CostaC Ferreira

Abstract

To evaluate whether the enalaprilat, angiotensin I enzyme conversion inhibitor, could prevent the left ventricular hypertrophy (LVH) induced by isoproterenol. Seventy two adult Wistar-EPM rats were divided into four groups: CON, control; ENA, treated with enalaprilat (1 mg/kg via subcutaneous (s.c.) for 8 days); ISO, treated with isoproterenol (0.3 mg via s.c. for 8 days) e ENA + ISO, treated with both drugs simultaneously. Each group had the arterial blood pressure, cardiac rate and the left ventricle (LV) weight determined in 10 animals. In 8 animals from each group a small sample was taken from the LV and stained with hematoxyline-eosine and picrosirius for morphometric and ultra-structural studies with optic and transmission electronic microscopy. The ISO group showed that the LV weight increased 47% in comparison with control. On the other hand the ENA + ISO group showed only 22.1% increase (p < or = 0.05). The morphometric and ultra-structural analyses revealed that isoproterenol induced cardiomyocite hypertrophy and augmented the content of the type I collagen in the cardiac interstitium. Enalaprilat inhibited the isoproterenol action on the cardiomyocite, avoiding partially the LVH and decreasing the content of collagen...Continue Reading

Citations

Jan 16, 2007·Canadian Journal of Physiology and Pharmacology·A Joel GrecoPhilip J Kadowitz
Aug 5, 2010·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Marcelo FerreiraCelso Ferreira
Jun 20, 2020·Drug and Chemical Toxicology·Juliana Cyrillo Guimarães da SilvaAndresa Heemann Betti

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